Human Gene MLNR (ENST00000218721.1_4) from GENCODE V47lift37

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Description: motilin receptor (from RefSeq NM_001507.1)
Gencode Transcript: ENST00000218721.1_4
Gencode Gene: ENSG00000102539.5_7
Transcript (Including UTRs)
Position: hg19 chr13:49,794,474-49,796,513 Size: 2,040 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr13:49,794,474-49,796,513 Size: 2,040 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr13:49,794,474-49,796,513)			mRNA (may differ from genome)		Protein (412 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: MTLR_HUMAN DESCRIPTION: RecName: Full=Motilin receptor; AltName: Full=G-protein coupled receptor 38; FUNCTION: Receptor for motilin. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed only in thyroid, stomach, and bone marrow. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MLNR Diseases sorted by gene-association score: gastroparesis (11), diabetic autonomic neuropathy (9), colonic pseudo-obstruction (4), constipation (3), functional gastric disease (2), functional colonic disease (2), stomach disease (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C541863 N-(3-fluorophenyl)-1-((4-(((3S)-3-methyl-1-piperazinyl)methyl)phenyl)acetyl)-4-piperidinamine D000535 Aluminum D004917 Erythromycin C103741 mitemcinal

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.16 RPKM in Testis Total median expression: 1.31 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR003905 - GHS1_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10324 - Serpentine type 7TM GPCR chemoreceptor Srw

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on O43193


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016520 growth hormone-releasing hormone receptor activity Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AB463896 - Synthetic construct DNA, clone: pF1KB7426, Homo sapiens MLNR gene for motilin receptor, without stop codon, in Flexi system. BC148475 - Synthetic construct Homo sapiens clone IMAGE:100015417, MGC:183027 motilin receptor (MLNR) mRNA, encodes complete protein. AY603964 - Homo sapiens motilin/ghrelin receptor mRNA, complete cds.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O43193 (Reactome details) participates in the following event(s): R-HSA-444208 MLNR (GPR38) is a receptor for motilin R-HSA-749452 The Ligand:GPCR:Gq complex dissociates R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: GPR38, MTLR, MTLR1, MTLR_HUMAN, NM_001507, O43193, uc317cvv.1, uc317cvv.2 UCSC ID: ENST00000218721.1_4 RefSeq Accession: NM_001507.1 Protein: O43193 (aka MTLR_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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