Human Gene MLF2 (ENST00000203630.10_9) from GENCODE V47lift37

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Description: myeloid leukemia factor 2, transcript variant 2 (from RefSeq NM_001382226.1)
Gencode Transcript: ENST00000203630.10_9
Gencode Gene: ENSG00000089693.11_12
Transcript (Including UTRs)
Position: hg19 chr12:6,857,162-6,862,307 Size: 5,146 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr12:6,857,961-6,861,500 Size: 3,540 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:6,857,162-6,862,307)			mRNA (may differ from genome)		Protein (248 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MLF2 Diseases sorted by gene-association score: myeloid leukemia (14), leukemia (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015127 9,10-Dimethyl-1,2-benzanthracene D000082 Acetaminophen D001241 Aspirin D001564 Benzo(a)pyrene D002794 Choline D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D005419 Flavonoids D005492 Folic Acid more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 94.29 RPKM in Brain - Frontal Cortex (BA9) Total median expression: 2796.78 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-111.10	231	-0.481	Picture	PostScript	Text
3' UTR	-162.90	577	-0.282	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR019376 - Myeloid_leukemia_factor

Pfam Domains:
PF10248 - Myelodysplasia-myeloid leukemia factor 1-interacting protein
PF12927 - Domain of unknown function (DUF3835)

ModBase Predicted Comparative 3D Structure on Q5U0N1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	BC002340 - Homo sapiens myeloid leukemia factor 2, mRNA (cDNA clone MGC:8380 IMAGE:2820309), complete cds. AF070539 - Homo sapiens clone 24433 myelodysplasia/myeloid leukemia factor 2 mRNA, complete cds. U57342 - Human myelodysplasia/myeloid leukemia factor 2 (MLF2) mRNA, complete cds. BC000898 - Homo sapiens myeloid leukemia factor 2, mRNA (cDNA clone MGC:5310 IMAGE:2900086), complete cds. JD528820 - Sequence 509844 from Patent EP1572962. JD048345 - Sequence 29369 from Patent EP1572962. JD186200 - Sequence 167224 from Patent EP1572962. JD335731 - Sequence 316755 from Patent EP1572962. JD322337 - Sequence 303361 from Patent EP1572962. JD158336 - Sequence 139360 from Patent EP1572962. JD131744 - Sequence 112768 from Patent EP1572962. JD111550 - Sequence 92574 from Patent EP1572962. JD521001 - Sequence 502025 from Patent EP1572962. JD184599 - Sequence 165623 from Patent EP1572962. JD057647 - Sequence 38671 from Patent EP1572962. JD121908 - Sequence 102932 from Patent EP1572962. JD458930 - Sequence 439954 from Patent EP1572962. JD082664 - Sequence 63688 from Patent EP1572962. JD175219 - Sequence 156243 from Patent EP1572962. AK289869 - Homo sapiens cDNA FLJ78094 complete cds, highly similar to Homo sapiens myeloid leukemia factor 2, mRNA. JD427261 - Sequence 408285 from Patent EP1572962. AK313998 - Homo sapiens cDNA, FLJ94652, Homo sapiens myeloid leukemia factor 2 (MLF2), mRNA. KJ892467 - Synthetic construct Homo sapiens clone ccsbBroadEn_01861 MLF2 gene, encodes complete protein. BT019393 - Homo sapiens myeloid leukemia factor 2 mRNA, complete cds. BT019432 - Homo sapiens myeloid leukemia factor 2 mRNA, complete cds. CR541700 - Homo sapiens full open reading frame cDNA clone RZPDo834F0728D for gene MLF2, myeloid leukemia factor 2; complete cds, without stopcodon. JD331944 - Sequence 312968 from Patent EP1572962. JD217737 - Sequence 198761 from Patent EP1572962. JD485665 - Sequence 466689 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000203630.1, ENST00000203630.2, ENST00000203630.3, ENST00000203630.4, ENST00000203630.5, ENST00000203630.6, ENST00000203630.7, ENST00000203630.8, ENST00000203630.9, hCG_25928 , MLF2 , NM_001382226, Q5U0N1, Q5U0N1_HUMAN, uc317ciz.1, uc317ciz.2 UCSC ID: ENST00000203630.10_9 RefSeq Accession: NM_001382226.1 Protein: Q5U0N1

Gene Model Information


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Methods, Credits, and Use Restrictions


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