The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23368
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003824 catalytic activity GO:0004470 malic enzyme activity GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity GO:0008948 oxaloacetate decarboxylase activity GO:0009055 electron carrier activity GO:0016491 oxidoreductase activity GO:0046872 metal ion binding GO:0051287 NAD binding
Biological Process: GO:0006090 pyruvate metabolic process GO:0006099 tricarboxylic acid cycle GO:0006108 malate metabolic process GO:0008152 metabolic process GO:0022900 electron transport chain GO:0055114 oxidation-reduction process GO:1902031 regulation of NADP metabolic process
BioCyc Knowledge Library MALATE-ASPARTATE-SHUTTLE-PWY - malate-aspartate shuttle PWY66-398 - TCA cycle PWY66-399 - gluconeogenesis PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein P23368 (Reactome details) participates in the following event(s):
R-HSA-9012268 ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR R-HSA-71403 Citric acid cycle (TCA cycle) R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
