ID:MAEA_HUMAN DESCRIPTION: RecName: Full=Macrophage erythroblast attacher; AltName: Full=Cell proliferation-inducing gene 5 protein; AltName: Full=Erythroblast macrophage protein; AltName: Full=Human lung cancer oncogene 10 protein; Short=HLC-10; FUNCTION: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. SUBUNIT: Forms a complex with F-actin. SUBCELLULAR LOCATION: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern. TISSUE SPECIFICITY: Ubiquitous. DEVELOPMENTAL STAGE: Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis. SIMILARITY: Contains 1 CTLH domain. SIMILARITY: Contains 1 LisH domain. SEQUENCE CAUTION: Sequence=AAC67543.1; Type=Erroneous termination; Positions=397; Note=Translated as stop; Sequence=AAC67543.1; Type=Frameshift; Positions=253, 327; Sequence=AAC67543.1; Type=Miscellaneous discrepancy; Note=Sequence differs at N-terminus; Sequence=AAO85220.1; Type=Erroneous initiation; Sequence=AK128302; Type=Miscellaneous discrepancy; Note=Intron retention;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7L5Y9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
