Human Gene MADD (ENST00000706887.1_4) from GENCODE V47lift37

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Description: MAP kinase activating death domain, transcript variant 14 (from RefSeq NM_001376574.1)
Gencode Transcript: ENST00000706887.1_4
Gencode Gene: ENSG00000110514.20_17
Transcript (Including UTRs)
Position: hg19 chr11:47,291,684-47,351,582 Size: 59,899 Total Exon Count: 37 Strand: +
Coding Region
Position: hg19 chr11:47,295,466-47,350,701 Size: 55,236 Coding Exon Count: 36

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	Microarray Expression
RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:47,291,684-47,351,582)			mRNA (may differ from genome)		Protein (1650 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C471674 10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone C023514 2,6-dinitrotoluene D015081 2-Naphthylamine D015127 9,10-Dimethyl-1,2-benzanthracene D000643 Ammonium Chloride D001241 Aspirin D002794 Choline D002922 Ciguatoxins D004052 Diethylnitrosamine more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-78.90	202	-0.391	Picture	PostScript	Text
3' UTR	-359.80	881	-0.408	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	U77352 - Homo sapiens MAP kinase-activating death domain protein (MADD) mRNA, complete cds. AF440100 - Homo sapiens insulinoma-glucagonoma protein 20 (IG20) mRNA, complete cds. AF440101 - Homo sapiens insulinoma-glucagonoma protein 20 pro-apoptotic splice variant (IG20) mRNA, complete cds, alternatively spliced. AF440102 - Homo sapiens insulinoma-glucagonoma protein 20 splice variant 2 (IG20) mRNA, complete cds, alternatively spliced. AF440103 - Homo sapiens insulinoma-glucagonoma protein 20 splice variant 3 (IG20) mRNA, complete cds, alternatively spliced. AF440434 - Homo sapiens insulinoma-glucagonoma protein 20 splice variant 4 (IG20) mRNA, complete cds. AK292442 - Homo sapiens cDNA FLJ78759 complete cds, highly similar to Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 3, mRNA. BC040484 - Homo sapiens MAP-kinase activating death domain, mRNA (cDNA clone MGC:33145 IMAGE:5271798), complete cds. AB002356 - Homo sapiens mRNA for KIAA0358 gene. U44953 - Homo sapiens DENN mRNA, complete cds. AB384466 - Synthetic construct DNA, clone: pF1KA0358, Homo sapiens MADD gene for MAP kinase-activating death domain protein, complete cds, without stop codon, in Flexi system. KJ897871 - Synthetic construct Homo sapiens clone ccsbBroadEn_07265 MADD gene, encodes complete protein. AK308780 - Homo sapiens cDNA, FLJ98821. JD466518 - Sequence 447542 from Patent EP1572962. JD175010 - Sequence 156034 from Patent EP1572962. JD368548 - Sequence 349572 from Patent EP1572962. JD398958 - Sequence 379982 from Patent EP1572962. JD203307 - Sequence 184331 from Patent EP1572962. CU691886 - Synthetic construct Homo sapiens gateway clone IMAGE:100023196 5' read MADD mRNA. AK092919 - Homo sapiens cDNA FLJ35600 fis, clone SPLEN2008737. AX747807 - Sequence 1332 from Patent EP1308459. AK093619 - Homo sapiens cDNA FLJ36300 fis, clone THYMU2004410. AX748227 - Sequence 1752 from Patent EP1308459. JD437662 - Sequence 418686 from Patent EP1572962. JD209864 - Sequence 190888 from Patent EP1572962. JD224600 - Sequence 205624 from Patent EP1572962. JD136608 - Sequence 117632 from Patent EP1572962. JD467324 - Sequence 448348 from Patent EP1572962. JD155267 - Sequence 136291 from Patent EP1572962. JD387372 - Sequence 368396 from Patent EP1572962. JD483038 - Sequence 464062 from Patent EP1572962. JD547436 - Sequence 528460 from Patent EP1572962. JD261769 - Sequence 242793 from Patent EP1572962. JD172106 - Sequence 153130 from Patent EP1572962. JD155525 - Sequence 136549 from Patent EP1572962. JD043975 - Sequence 24999 from Patent EP1572962. JD081754 - Sequence 62778 from Patent EP1572962. JD178565 - Sequence 159589 from Patent EP1572962. JD340562 - Sequence 321586 from Patent EP1572962. JD065477 - Sequence 46501 from Patent EP1572962. JD045440 - Sequence 26464 from Patent EP1572962. JD416773 - Sequence 397797 from Patent EP1572962. JD474854 - Sequence 455878 from Patent EP1572962. JD337217 - Sequence 318241 from Patent EP1572962. JD545947 - Sequence 526971 from Patent EP1572962. JD423784 - Sequence 404808 from Patent EP1572962. JD361634 - Sequence 342658 from Patent EP1572962. JD363708 - Sequence 344732 from Patent EP1572962. JD409097 - Sequence 390121 from Patent EP1572962. JD330755 - Sequence 311779 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A9L9PXF1, A0A9L9PXF1_HUMAN, MADD , NM_001376574, uc331mzg.1, uc331mzg.2 UCSC ID: ENST00000706887.1_4 RefSeq Accession: NM_001376571.1

Gene Model Information


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Methods, Credits, and Use Restrictions


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