Human Gene KRTAP21-1 (ENST00000335093.5

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Human Gene KRTAP21-1 (ENST00000335093.5_7) from GENCODE V47lift37

Description: keratin associated protein 21-1 (from RefSeq NM_181619.2)
Gencode Transcript: ENST00000335093.5_7
Gencode Gene: ENSG00000187005.5_9
Transcript (Including UTRs)
Position: hg19 chr21:32,127,333-32,127,746 Size: 414 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr21:32,127,457-32,127,696 Size: 240 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr21:32,127,333-32,127,746)			mRNA (may differ from genome)		Protein (79 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: KR211_HUMAN DESCRIPTION: RecName: Full=Keratin-associated protein 21-1; FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. SUBUNIT: Interacts with hair keratins (By similarity).

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000535 Aluminum

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.00 RPKM in (null) Total median expression: 0.00 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-3.30	50	-0.066	Picture	PostScript	Text
3' UTR	-22.50	124	-0.181	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

ModBase Predicted Comparative 3D Structure on Q3LI58


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0031424 keratinization Cellular Component: GO:0005829 cytosol GO:0005882 intermediate filament

Descriptions from all associated GenBank mRNAs


	AB096960 - Homo sapiens KRTAP21-1 mRNA for keratin associated protein, complete cds. BC105029 - Homo sapiens keratin associated protein 21-1, mRNA (cDNA clone MGC:132689 IMAGE:8144032), complete cds. BC105031 - Homo sapiens keratin associated protein 21-1, mRNA (cDNA clone MGC:132691 IMAGE:8144034), complete cds. JD152672 - Sequence 133696 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q3LI58 (Reactome details) participates in the following event(s): R-HSA-6805567 Keratinization R-HSA-1266738 Developmental Biology

Other Names for This Gene


	Alternate Gene Symbols: ENST00000335093.1, ENST00000335093.2, ENST00000335093.3, ENST00000335093.4, KAP21.1, KR211_HUMAN, NM_181619, Q3LI58, uc317udx.1, uc317udx.2 UCSC ID: ENST00000335093.5_7 RefSeq Accession: NM_181619.2 Protein: Q3LI58 (aka KR211_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.