Human Gene KRTAP1-4 (ENST00000377747.5_6) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: KRA14_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 1-4; AltName: Full=High sulfur keratin-associated protein 1.4; AltName: Full=Keratin-associated protein 1.4;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
SUBUNIT: Interacts with hair keratins.
TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
SIMILARITY: Belongs to the KRTAP type 1 family.
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Primer design for this transcript
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR002494 - Keratin-assoc
Pfam Domains:
PF01500 - Keratin, high sulfur B2 protein
PF13885 - Keratin, high sulfur B2 protein
ModBase Predicted Comparative 3D Structure on P0C5Y4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
| Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
| No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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LF209331 - JP 2014500723-A/16834: Polycomb-Associated Non-Coding RNAs.
LF327742 - JP 2014500723-A/135245: Polycomb-Associated Non-Coding RNAs.
JD031786 - Sequence 12810 from Patent EP1572962.
MA563319 - JP 2018138019-A/135245: Polycomb-Associated Non-Coding RNAs.
MA444908 - JP 2018138019-A/16834: Polycomb-Associated Non-Coding RNAs.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: A6NJ92, ENST00000377747.1, ENST00000377747.2, ENST00000377747.3, ENST00000377747.4, KAP1.4, KRA14_HUMAN, KRTAP1.4, NM_001257305, P0C5Y4, uc318nva.1, uc318nva.2
UCSC ID: ENST00000377747.5_6
RefSeq Accession: NM_001257305.2
Protein: P0C5Y4
(aka KRA14_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
