Human Gene NHSL3 (ENST00000294521.7_2) from GENCODE V47lift37
  Description: KIAA1522, transcript variant 3 (from RefSeq NM_001198973.2)
Gencode Transcript: ENST00000294521.7_2
Gencode Gene: ENSG00000162522.11_13
Transcript (Including UTRs)
   Position: hg19 chr1:33,231,235-33,238,798 Size: 7,564 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:33,231,371-33,238,488 Size: 7,118 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:33,231,235-33,238,798)mRNA (may differ from genome)Protein (143 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K1522_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein KIAA1522;
SEQUENCE CAUTION: Sequence=BAA96046.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.53 RPKM in Adrenal Gland
Total median expression: 770.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.10136-0.398 Picture PostScript Text
3' UTR -109.10310-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9P206
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0030154 cell differentiation


-  Descriptions from all associated GenBank mRNAs
  BC156342 - Synthetic construct Homo sapiens clone IMAGE:100061909, MGC:190125 KIAA1522 (KIAA1522) mRNA, encodes complete protein.
AB384615 - Synthetic construct DNA, clone: pF1KA1522, Homo sapiens KIAA1522 gene for KIAA1522 protein, complete cds, without stop codon, in Flexi system.
AK298965 - Homo sapiens cDNA FLJ60810 complete cds.
AB040955 - Homo sapiens KIAA1522 mRNA for KIAA1522 protein.
JD423795 - Sequence 404819 from Patent EP1572962.
JD175177 - Sequence 156201 from Patent EP1572962.
JD347024 - Sequence 328048 from Patent EP1572962.
AL713671 - Homo sapiens mRNA; cDNA DKFZp727C231 (from clone DKFZp727C231).
JD131595 - Sequence 112619 from Patent EP1572962.
JD102262 - Sequence 83286 from Patent EP1572962.
JD049976 - Sequence 31000 from Patent EP1572962.
JD461701 - Sequence 442725 from Patent EP1572962.
JD134732 - Sequence 115756 from Patent EP1572962.
JD156243 - Sequence 137267 from Patent EP1572962.
JD511004 - Sequence 492028 from Patent EP1572962.
JD450212 - Sequence 431236 from Patent EP1572962.
JD354398 - Sequence 335422 from Patent EP1572962.
JD461502 - Sequence 442526 from Patent EP1572962.
JD400190 - Sequence 381214 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DQU8, B5MDY0, C9JH84, ENST00000294521.1, ENST00000294521.2, ENST00000294521.3, ENST00000294521.4, ENST00000294521.5, ENST00000294521.6, KIAA1522, NHSL3 , NHSL3_HUMAN, NM_001198973, Q8TCQ0, Q9P206, uc317lhh.1, uc317lhh.2
UCSC ID: ENST00000294521.7_2
RefSeq Accession: NM_001198973.2
Protein: Q9P206 (aka K1522_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.