Human Gene TMEM94 (ENST00000314256.12_10) from GENCODE V47lift37
  Description: transmembrane protein 94, transcript variant 1 (from RefSeq NM_014738.6)
Gencode Transcript: ENST00000314256.12_10
Gencode Gene: ENSG00000177728.17_20
Transcript (Including UTRs)
   Position: hg19 chr17:73,452,716-73,496,533 Size: 43,818 Total Exon Count: 32 Strand: +
Coding Region
   Position: hg19 chr17:73,467,987-73,495,415 Size: 27,429 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:73,452,716-73,496,533)mRNA (may differ from genome)Protein (1356 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K0195_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein KIAA0195; AltName: Full=Transmembrane protein 94;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed ubiquitously.
SEQUENCE CAUTION: Sequence=BAA12108.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.19 RPKM in Brain - Cerebellum
Total median expression: 939.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -84.40223-0.378 Picture PostScript Text
3' UTR -482.301118-0.431 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006068 - ATPase_P-typ_cation-transptr_C
IPR023298 - ATPase_P-typ_TM_dom

SCOP Domains:
81653 - Calcium ATPase, transduction domain A
81660 - Metal cation-transporting ATPase, ATP-binding domain N
81665 - Calcium ATPase, transmembrane domain M

ModBase Predicted Comparative 3D Structure on Q12767
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK308160 - Homo sapiens cDNA, FLJ98108.
BC042942 - Homo sapiens KIAA0195, mRNA (cDNA clone IMAGE:5295538), with apparent retained intron.
AK304819 - Homo sapiens cDNA FLJ58673 complete cds, highly similar to Transmembrane protein 94.
D83779 - Homo sapiens mRNA for KIAA0195 gene.
JD203685 - Sequence 184709 from Patent EP1572962.
JD058237 - Sequence 39261 from Patent EP1572962.
JD496022 - Sequence 477046 from Patent EP1572962.
BC045540 - Homo sapiens KIAA0195, mRNA (cDNA clone MGC:57170 IMAGE:5274473), complete cds.
JD057384 - Sequence 38408 from Patent EP1572962.
JD060774 - Sequence 41798 from Patent EP1572962.
JD438998 - Sequence 420022 from Patent EP1572962.
AB383792 - Synthetic construct DNA, clone: pF1KSDA0195, Homo sapiens KIAA0195 gene for KIAA0195 protein, complete cds, without stop codon, in Flexi system.
AK316060 - Homo sapiens cDNA, FLJ78959 complete cds, highly similar to Transmembrane protein 94.
AK294526 - Homo sapiens cDNA FLJ58177 complete cds, highly similar to Transmembrane protein 94.
CR936809 - Homo sapiens mRNA; cDNA DKFZp781M1056 (from clone DKFZp781M1056).
AK128508 - Homo sapiens cDNA FLJ46661 fis, clone TRACH3006717.
AK094864 - Homo sapiens cDNA FLJ37545 fis, clone BRCAN2027355.
AF070545 - Homo sapiens clone 24581 unknown mRNA.
JD394140 - Sequence 375164 from Patent EP1572962.
JD164993 - Sequence 146017 from Patent EP1572962.
JD122336 - Sequence 103360 from Patent EP1572962.
JD178191 - Sequence 159215 from Patent EP1572962.
JD497300 - Sequence 478324 from Patent EP1572962.
JD210361 - Sequence 191385 from Patent EP1572962.
JD389753 - Sequence 370777 from Patent EP1572962.
JD139259 - Sequence 120283 from Patent EP1572962.
JD164212 - Sequence 145236 from Patent EP1572962.
JD048275 - Sequence 29299 from Patent EP1572962.
JD210078 - Sequence 191102 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C9JL75, ENST00000314256.1, ENST00000314256.10, ENST00000314256.11, ENST00000314256.2, ENST00000314256.3, ENST00000314256.4, ENST00000314256.5, ENST00000314256.6, ENST00000314256.7, ENST00000314256.8, ENST00000314256.9, KIAA0195, NM_014738, O75536, Q12767, Q86XF1, TMEM94 , TMM94_HUMAN, uc317pox.1, uc317pox.2
UCSC ID: ENST00000314256.12_10
RefSeq Accession: NM_014738.6
Protein: Q12767 (aka K0195_HUMAN or K195_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.