ID:KCIP4_HUMAN DESCRIPTION: RecName: Full=Kv channel-interacting protein 4; Short=KChIP4; AltName: Full=A-type potassium channel modulatory protein 4; AltName: Full=Calsenilin-like protein; AltName: Full=Potassium channel-interacting protein 4; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity). SUBUNIT: Component of heteromultimeric potassium channels (By similarity). Interacts with KCND2. Interacts with KCND3, and the C-terminus of PSEN2 and probably PSEN1. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Predominantly expressed in brain. DOMAIN: The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current (By similarity). SIMILARITY: Belongs to the recoverin family. SIMILARITY: Contains 4 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00036 - EF hand PF10591 - Secreted protein acidic and rich in cysteine Ca binding region PF13202 - EF hand PF13405 - EF-hand domain PF13499 - EF-hand domain pair PF13833 - EF-hand domain pair
SCOP Domains: 63446 - Type I dockerin domain 47473 - EF-hand
ModBase Predicted Comparative 3D Structure on Q6PIL6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0071805 potassium ion transmembrane transport GO:0072659 protein localization to plasma membrane GO:1901379 regulation of potassium ion transmembrane transport
AK290998 - Homo sapiens cDNA FLJ75928 complete cds, highly similar to Homo sapiens Kv channel interacting protein 4 (KCNIP4), transcript variant 4, mRNA. DQ148490 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced. DQ148491 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced. AK294188 - Homo sapiens cDNA FLJ59677 complete cds, highly similar to Kv channel-interacting protein 4. DQ148492 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced. AY118170 - Homo sapiens potassium channel-interacting protein KCHIP4.4 (KCNIP4) mRNA, complete cds, alternatively spliced. DQ148489 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced. BX648990 - Homo sapiens mRNA; cDNA DKFZp686J0484 (from clone DKFZp686J0484). AK289661 - Homo sapiens cDNA FLJ75905 complete cds, highly similar to Homo sapiens Kv channel interacting protein 4 (KCNIP4), transcript variant 2, mRNA. AK289922 - Homo sapiens cDNA FLJ75910 complete cds, highly similar to Homo sapiens Kv channel interacting protein 4 (KCNIP4), transcript variant 1, mRNA. BC032520 - Homo sapiens Kv channel interacting protein 4, mRNA (cDNA clone MGC:44947 IMAGE:5494835), complete cds. AF367024 - Homo sapiens KCHIP4.2 (KCNIP4) mRNA, complete cds, alternatively spliced. AF367023 - Homo sapiens KCHIP4.1 (KCNIP4) mRNA, complete cds, alternatively spliced. AF453246 - Homo sapiens potassium channel interacting protein 4b short isoform mRNA, complete cds; alternatively spliced. AY029176 - Homo sapiens KChIP4.3 variant (KCHIP4) mRNA, complete cds, alternatively spliced. AF302044 - Homo sapiens calsenilin-like protein (CALP) mRNA, complete cds. DQ148488 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced. AF305072 - Homo sapiens calsenilin-like protein (CALP) mRNA, complete cds, alternatively spliced. AK314058 - Homo sapiens cDNA, FLJ94724. DQ148487 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced. KJ899636 - Synthetic construct Homo sapiens clone ccsbBroadEn_09030 KCNIP4 gene, encodes complete protein. EU446535 - Synthetic construct Homo sapiens clone IMAGE:100069863; IMAGE:100011744; FLH257045.01L Kv channel interacting protein 4 (KCNIP4) gene, encodes complete protein. AB528608 - Synthetic construct DNA, clone: pF1KB5158, Homo sapiens KCNIP4 gene for Kv channel interacting protein 4, without stop codon, in Flexi system. JD301479 - Sequence 282503 from Patent EP1572962. JD495349 - Sequence 476373 from Patent EP1572962. JD244097 - Sequence 225121 from Patent EP1572962. JD503280 - Sequence 484304 from Patent EP1572962. JD444877 - Sequence 425901 from Patent EP1572962. JD529865 - Sequence 510889 from Patent EP1572962. JD289277 - Sequence 270301 from Patent EP1572962. JD377369 - Sequence 358393 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6PIL6 (Reactome details) participates in the following event(s):
R-HSA-5577234 KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels R-HSA-5576891 Cardiac conduction R-HSA-397014 Muscle contraction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
