ID:KCNH1_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily H member 1; AltName: Full=Ether-a-go-go potassium channel 1; Short=EAG channel 1; Short=h-eag; Short=hEAG1; AltName: Full=Voltage-gated potassium channel subunit Kv10.1; FUNCTION: Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts. SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B (By similarity). INTERACTION: P62158:CALM3; NbExp=2; IntAct=EBI-2909270, EBI-397435; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Note=Perinuclear KCNH1 is located to NPC-free islands. TISSUE SPECIFICITY: Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. SIMILARITY: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. SIMILARITY: Contains 1 cyclic nucleotide-binding domain. SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 1 PAS (PER-ARNT-SIM) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/KCNH1ID41048ch1q32.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95259
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000155 phosphorelay sensor kinase activity GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005251 delayed rectifier potassium channel activity GO:0005267 potassium channel activity GO:0005515 protein binding GO:0005516 calmodulin binding GO:0008289 lipid binding GO:0019901 protein kinase binding GO:0042802 identical protein binding GO:0044325 ion channel binding GO:0046982 protein heterodimerization activity GO:0071889 14-3-3 protein binding GO:1902936 phosphatidylinositol bisphosphate binding GO:0030551 cyclic nucleotide binding
Biological Process: GO:0000160 phosphorelay signal transduction system GO:0001964 startle response GO:0006811 ion transport GO:0006813 potassium ion transport GO:0007520 myoblast fusion GO:0023014 signal transduction by protein phosphorylation GO:0034220 ion transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0042127 regulation of cell proliferation GO:0042391 regulation of membrane potential GO:0048015 phosphatidylinositol-mediated signaling GO:0055085 transmembrane transport GO:0071277 cellular response to calcium ion GO:0071805 potassium ion transmembrane transport
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
