ID:KCNC1_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily C member 1; AltName: Full=NGK2; AltName: Full=Voltage-gated potassium channel subunit Kv3.1; AltName: Full=Voltage-gated potassium channel subunit Kv4; FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. SUBUNIT: Heteromultimer with KCNG3, KCNG4 and KCNV2. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. DOMAIN: The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. SIMILARITY: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48547
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0007420 brain development GO:0009636 response to toxic substance GO:0009642 response to light intensity GO:0010996 response to auditory stimulus GO:0014075 response to amine GO:0021549 cerebellum development GO:0021759 globus pallidus development GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035690 cellular response to drug GO:0035864 response to potassium ion GO:0051260 protein homooligomerization GO:0051262 protein tetramerization GO:0055085 transmembrane transport GO:0071774 response to fibroblast growth factor GO:0071805 potassium ion transmembrane transport GO:1901379 regulation of potassium ion transmembrane transport GO:1901381 positive regulation of potassium ion transmembrane transport GO:1903818 positive regulation of voltage-gated potassium channel activity GO:1990089 response to nerve growth factor
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
