The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
ModBase Predicted Comparative 3D Structure on Q96ST2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC017012 - Homo sapiens IWS1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3914688), complete cds. AK001717 - Homo sapiens cDNA FLJ10855 fis, clone NT2RP4001524. AL834178 - Homo sapiens mRNA; cDNA DKFZp761G0123 (from clone DKFZp761G0123). AK296848 - Homo sapiens cDNA FLJ54017 complete cds, highly similar to IWS1 homolog. AK027561 - Homo sapiens cDNA FLJ14655 fis, clone NT2RP2002292. JD506516 - Sequence 487540 from Patent EP1572962. AK056881 - Homo sapiens cDNA FLJ32319 fis, clone PROST2003472. JD248848 - Sequence 229872 from Patent EP1572962. BC110536 - Homo sapiens IWS1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:126375 IMAGE:40035173), complete cds. BC110537 - Homo sapiens IWS1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:126376 IMAGE:40035174), complete cds. JD431710 - Sequence 412734 from Patent EP1572962. AK294669 - Homo sapiens cDNA FLJ53983 complete cds, highly similar to IWS1 homolog. AK000868 - Homo sapiens cDNA FLJ10006 fis, clone HEMBA1000168, weakly similar to CYLICIN I. AK295970 - Homo sapiens cDNA FLJ59547 complete cds, highly similar to IWS1 homolog. KJ902855 - Synthetic construct Homo sapiens clone ccsbBroadEn_12249 IWS1 gene, encodes complete protein. BC065279 - Homo sapiens IWS1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:6172830), partial cds. AK309006 - Homo sapiens cDNA, FLJ99047. JD398198 - Sequence 379222 from Patent EP1572962. JD373941 - Sequence 354965 from Patent EP1572962. JD404958 - Sequence 385982 from Patent EP1572962. JD522885 - Sequence 503909 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96ST2 (Reactome details) participates in the following event(s):
R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
