ID:CENPR_HUMAN DESCRIPTION: RecName: Full=Centromere protein R; Short=CENP-R; AltName: Full=Beta-3-endonexin; AltName: Full=Integrin beta-3-binding protein; AltName: Full=Nuclear receptor-interacting factor 3; FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. SUBUNIT: Homodimer; mediated by the coiled coil domain. Isoform 3, but not other isoforms, interacts with the cytoplasmic tail of integrin ITGB3. The relevance of the interaction with ITGB3 is however uncertain, since isoform 3 is mainly nuclear. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. SUBCELLULAR LOCATION: Isoform 1: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. SUBCELLULAR LOCATION: Isoform 2: Nucleus. SUBCELLULAR LOCATION: Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic. SUBCELLULAR LOCATION: Isoform 4: Cytoplasm. TISSUE SPECIFICITY: Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. INDUCTION: By estrogen. DOMAIN: The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis. DOMAIN: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known to be important for the association with nuclear receptors. Such motif, which is required for an efficient association with nuclear receptors, is however not essential. DOMAIN: Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors. SEQUENCE CAUTION: Sequence=AAH14385.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13352
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC009929 - Homo sapiens integrin beta 3 binding protein (beta3-endonexin), mRNA (cDNA clone MGC:796 IMAGE:3505579), complete cds. BC014385 - Homo sapiens integrin beta 3 binding protein (beta3-endonexin), mRNA (cDNA clone MGC:24383 IMAGE:4064625), complete cds. AF175306 - Homo sapiens nuclear receptor co-activator NRIF3 (NRIF3) mRNA, alternatively spliced, complete cds. U37139 - Homo sapiens beta 3-endonexin long form mRNA, complete cds, alternatively spliced. AK312944 - Homo sapiens cDNA, FLJ93397, Homo sapiens integrin beta 3 binding protein (beta3-endonexin)(ITGB3BP), mRNA. KJ893369 - Synthetic construct Homo sapiens clone ccsbBroadEn_02763 ITGB3BP gene, encodes complete protein. AB528591 - Synthetic construct DNA, clone: pF1KB7575, Homo sapiens ITGB3BP gene for integrin beta 3 binding protein, without stop codon, in Flexi system. AK309622 - Homo sapiens cDNA, FLJ99663. DM110836 - Novel Cancer Marker and Use Thereof. JD350413 - Sequence 331437 from Patent EP1572962. JD543649 - Sequence 524673 from Patent EP1572962. JD353535 - Sequence 334559 from Patent EP1572962. KJ906090 - Synthetic construct Homo sapiens clone ccsbBroadEn_15760 ITGB3BP gene, encodes complete protein. JD020248 - Sequence 1272 from Patent EP1572962. JD034517 - Sequence 15541 from Patent EP1572962. JD034446 - Sequence 15470 from Patent EP1572962. JD020244 - Sequence 1268 from Patent EP1572962. JD347302 - Sequence 328326 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13352 (Reactome details) participates in the following event(s):
R-HSA-193677 NRIF binds to p75NTR R-HSA-205118 TRAF6 polyubiquitinates NRIF R-HSA-205112 gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 R-HSA-204947 Polyubiquitinated NRIF migrates to the nucleus R-HSA-205008 Polyubiquitinated NRIF binds to p62 (Sequestosome) R-HSA-193669 TRAF6 binds to p75NTR:NRIF R-HSA-606349 Mis18 complex binds the centromere R-HSA-606326 HJURP:CENPA complex localizes to the centromere R-HSA-204949 NRIF and TRAF6 may activate JNK R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-205043 NRIF signals cell death from the nucleus R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-774815 Nucleosome assembly R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-73887 Death Receptor Signalling R-HSA-73886 Chromosome Maintenance R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
