Human Gene ISOC1 (ENST00000173527.6_4) from GENCODE V47lift37

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Description: isochorismatase domain containing 1 (from RefSeq NM_016048.2)
Gencode Transcript: ENST00000173527.6_4
Gencode Gene: ENSG00000066583.12_10
Transcript (Including UTRs)
Position: hg19 chr5:128,430,442-128,449,721 Size: 19,280 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr5:128,430,460-128,448,694 Size: 18,235 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:128,430,442-128,449,721)			mRNA (may differ from genome)		Protein (298 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ISOC1_HUMAN DESCRIPTION: RecName: Full=Isochorismatase domain-containing protein 1; SIMILARITY: Belongs to the isochorismatase family. SEQUENCE CAUTION: Sequence=AAH08367.1; Type=Erroneous initiation; Sequence=AAH14105.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate C016403 2,4-dinitrotoluene D000082 Acetaminophen D016604 Aflatoxin B1 D001151 Arsenic D002794 Choline D002994 Clofibrate D019327 Copper Sulfate D016572 Cyclosporine D004997 Ethinyl Estradiol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 29.11 RPKM in Uterus Total median expression: 615.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-0.50	18	-0.028	Picture	PostScript	Text
3' UTR	-203.90	1027	-0.199	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000868 - Isochorismatase-like

Pfam Domains:
PF00857 - Isochorismatase family

SCOP Domains:
52499 - Isochorismatase-like hydrolases

ModBase Predicted Comparative 3D Structure on Q96CN7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details			Gene Details
Gene Sorter			Gene Sorter
		Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0003824 catalytic activity GO:0005515 protein binding Biological Process: GO:0008150 biological_process GO:0008152 metabolic process Cellular Component: GO:0005737 cytoplasm GO:0005777 peroxisome

Descriptions from all associated GenBank mRNAs


	AF151869 - Homo sapiens CGI-111 protein mRNA, complete cds. AK025787 - Homo sapiens cDNA: FLJ22134 fis, clone HEP20665, highly similar to AF151869 Homo sapiens CGI-111 protein mRNA. BC014105 - Homo sapiens isochorismatase domain containing 1, mRNA (cDNA clone MGC:20632 IMAGE:4129769), complete cds. DQ895427 - Synthetic construct Homo sapiens clone IMAGE:100009887; FLH184295.01L; RZPDo839E04143D isochorismatase domain containing 1 (ISOC1) gene, encodes complete protein. BC008367 - Homo sapiens isochorismatase domain containing 1, mRNA (cDNA clone MGC:721 IMAGE:3355904), complete cds. JD126046 - Sequence 107070 from Patent EP1572962. JD217872 - Sequence 198896 from Patent EP1572962. JD240300 - Sequence 221324 from Patent EP1572962. KJ902540 - Synthetic construct Homo sapiens clone ccsbBroadEn_11934 ISOC1 gene, encodes complete protein. KJ902541 - Synthetic construct Homo sapiens clone ccsbBroadEn_11935 ISOC1 gene, encodes complete protein. CU678931 - Synthetic construct Homo sapiens gateway clone IMAGE:100022430 5' read ISOC1 mRNA. DQ892226 - Synthetic construct Homo sapiens clone IMAGE:100004856; FLH263558.01X; RZPDo839E04144D isochorismatase domain containing 1 (ISOC1) gene, encodes complete protein. JD297356 - Sequence 278380 from Patent EP1572962. JD530414 - Sequence 511438 from Patent EP1572962. JD491027 - Sequence 472051 from Patent EP1572962. JD257442 - Sequence 238466 from Patent EP1572962. JD226211 - Sequence 207235 from Patent EP1572962. JD498985 - Sequence 480009 from Patent EP1572962. JD282681 - Sequence 263705 from Patent EP1572962. JD285798 - Sequence 266822 from Patent EP1572962. JD173908 - Sequence 154932 from Patent EP1572962. JD553626 - Sequence 534650 from Patent EP1572962. JD565823 - Sequence 546847 from Patent EP1572962. JD305700 - Sequence 286724 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: CGI-111, ENST00000173527.1, ENST00000173527.2, ENST00000173527.3, ENST00000173527.4, ENST00000173527.5, ISOC1_HUMAN, NM_016048, Q7Z770, Q96CN7, uc317cei.1, uc317cei.2 UCSC ID: ENST00000173527.6_4 RefSeq Accession: NM_016048.2 Protein: Q96CN7 (aka ISOC1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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