ID:IREB2_HUMAN DESCRIPTION: RecName: Full=Iron-responsive element-binding protein 2; Short=IRE-BP 2; AltName: Full=Iron regulatory protein 2; Short=IRP2; FUNCTION: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity). 4Fe- 4S-binding affects RNA-binding activity, thereby inhibiting activity of the protein (By similarity). SUBUNIT: Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5. SUBCELLULAR LOCATION: Cytoplasm. PTM: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity. SIMILARITY: Belongs to the aconitase/IPM isomerase family. SEQUENCE CAUTION: Sequence=AAA79926.1; Type=Frameshift; Positions=605, 611; Sequence=BAD92640.1; Type=Frameshift; Positions=727;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48200
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006826 iron ion transport GO:0006879 cellular iron ion homeostasis GO:0008152 metabolic process GO:0017148 negative regulation of translation
AB209403 - Homo sapiens mRNA for iron-responsive element binding protein 2 variant protein. AK292992 - Homo sapiens cDNA FLJ77383 complete cds, highly similar to Homo sapiens iron-responsive element binding protein 2 (IREB2), mRNA. BC117481 - Homo sapiens iron-responsive element binding protein 2, mRNA (cDNA clone MGC:151090 IMAGE:40126032), complete cds. BC117483 - Homo sapiens iron-responsive element binding protein 2, mRNA (cDNA clone MGC:151092 IMAGE:40126034), complete cds. BC143948 - Homo sapiens cDNA clone IMAGE:9052466. M58511 - Human iron-responsive element-binding protein/iron regulatory protein 2 (IRE-BP2/IRP2) mRNA, partial cds. HQ258663 - Synthetic construct Homo sapiens clone IMAGE:100072693 iron-responsive element binding protein 2 (IREB2) gene, encodes complete protein. U20180 - Human iron-regulatory protein 2 (IRP2) mRNA, partial cds. AK027033 - Homo sapiens cDNA: FLJ23380 fis, clone HEP16267, highly similar to HUMIREBPA Human iron-responsive element-binding protein/iron regulatory protein 2 (IRE-BP2/IRP2) mRNA. AK027034 - Homo sapiens cDNA: FLJ23381 fis, clone HEP16268, highly similar to HUMIREBPA Human iron-responsive element-binding protein/iron regulatory protein 2 (IRE-BP2/IRP2) mRNA. BC017880 - Homo sapiens iron-responsive element binding protein 2, mRNA (cDNA clone IMAGE:4277855), complete cds. JD141737 - Sequence 122761 from Patent EP1572962. KJ905815 - Synthetic construct Homo sapiens clone ccsbBroadEn_15485 IREB2 gene, encodes complete protein. AB586699 - Homo sapiens IREB2 variant mRNA for iron-responsive element binding protein 2 variant, complete cds. AL133439 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 200978. JD524796 - Sequence 505820 from Patent EP1572962. JD493724 - Sequence 474748 from Patent EP1572962. JD359175 - Sequence 340199 from Patent EP1572962. JD300720 - Sequence 281744 from Patent EP1572962. JD546930 - Sequence 527954 from Patent EP1572962. JD371007 - Sequence 352031 from Patent EP1572962. JD171389 - Sequence 152413 from Patent EP1572962. JD248919 - Sequence 229943 from Patent EP1572962. JD110798 - Sequence 91822 from Patent EP1572962. JD510386 - Sequence 491410 from Patent EP1572962. JD090877 - Sequence 71901 from Patent EP1572962. JD037251 - Sequence 18275 from Patent EP1572962. JD281845 - Sequence 262869 from Patent EP1572962. JD293667 - Sequence 274691 from Patent EP1572962. JD271150 - Sequence 252174 from Patent EP1572962. JD192985 - Sequence 174009 from Patent EP1572962. JD136837 - Sequence 117861 from Patent EP1572962. JD071900 - Sequence 52924 from Patent EP1572962. JD203723 - Sequence 184747 from Patent EP1572962. JD560643 - Sequence 541667 from Patent EP1572962. JD476622 - Sequence 457646 from Patent EP1572962. JD132160 - Sequence 113184 from Patent EP1572962. AL117613 - Homo sapiens mRNA; cDNA DKFZp564D1164 (from clone DKFZp564D1164). JD506268 - Sequence 487292 from Patent EP1572962. JD223646 - Sequence 204670 from Patent EP1572962. JD553258 - Sequence 534282 from Patent EP1572962. JD040570 - Sequence 21594 from Patent EP1572962. JD552656 - Sequence 533680 from Patent EP1572962. JD261037 - Sequence 242061 from Patent EP1572962. JD094418 - Sequence 75442 from Patent EP1572962. JD245492 - Sequence 226516 from Patent EP1572962. JD045901 - Sequence 26925 from Patent EP1572962. JD368373 - Sequence 349397 from Patent EP1572962. JD490783 - Sequence 471807 from Patent EP1572962. JD503307 - Sequence 484331 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P48200 (Reactome details) participates in the following event(s):
R-HSA-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 R-HSA-5690886 ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs R-HSA-917937 Iron uptake and transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
