ID:IFIT1_HUMAN DESCRIPTION: RecName: Full=Interferon-induced protein with tetratricopeptide repeats 1; Short=IFIT-1; AltName: Full=Interferon-induced 56 kDa protein; Short=IFI-56K; Short=P56; FUNCTION: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. SUBUNIT: Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication. INTERACTION: P09913:IFIT2; NbExp=5; IntAct=EBI-745117, EBI-3507167; O14879:IFIT3; NbExp=5; IntAct=EBI-745117, EBI-745127; SUBCELLULAR LOCATION: Cytoplasm. INDUCTION: By type I interferons, dsRNAs and viruses. PTM: Phosphorylated. SIMILARITY: Belongs to the IFIT family. SIMILARITY: Contains 10 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09914
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0009615 response to virus GO:0016032 viral process GO:0019060 intracellular transport of viral protein in host cell GO:0032091 negative regulation of protein binding GO:0045070 positive regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0045087 innate immune response GO:0050688 regulation of defense response to virus GO:0050689 negative regulation of defense response to virus by host GO:0051097 negative regulation of helicase activity GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0071357 cellular response to type I interferon GO:0071360 cellular response to exogenous dsRNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
