Human Gene HSPA13 (ENST00000285667.4_7) from GENCODE V47lift37
  Description: heat shock protein family A (Hsp70) member 13 (from RefSeq NM_006948.5)
Gencode Transcript: ENST00000285667.4_7
Gencode Gene: ENSG00000155304.6_9
Transcript (Including UTRs)
   Position: hg19 chr21:15,743,436-15,755,467 Size: 12,032 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr21:15,745,938-15,755,440 Size: 9,503 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:15,743,436-15,755,467)mRNA (may differ from genome)Protein (471 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HSP13_HUMAN
DESCRIPTION: RecName: Full=Heat shock 70 kDa protein 13; AltName: Full=Microsomal stress-70 protein ATPase core; AltName: Full=Stress-70 protein chaperone microsome-associated 60 kDa protein; Flags: Precursor;
FUNCTION: Has peptide-independent ATPase activity.
SUBUNIT: Binds UBQLN2.
SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum.
TISSUE SPECIFICITY: Constitutively expressed in all tissues.
SIMILARITY: Belongs to the heat shock protein 70 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.30 RPKM in Pituitary
Total median expression: 343.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.3027-0.344 Picture PostScript Text
3' UTR -553.402502-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018181 - Heat_shock_70_CS
IPR013126 - Hsp_70_fam

Pfam Domains:
PF00012 - Hsp70 protein
PF06723 - MreB/Mbl protein

SCOP Domains:
53067 - Actin-like ATPase domain

ModBase Predicted Comparative 3D Structure on P48723
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF210647 - JP 2014500723-A/18150: Polycomb-Associated Non-Coding RNAs.
BC017580 - Homo sapiens, clone IMAGE:4132509, mRNA.
BC036370 - Homo sapiens heat shock protein 70kDa family, member 13, mRNA (cDNA clone MGC:26248 IMAGE:4837136), complete cds.
HM005612 - Homo sapiens clone HTL-S-199a testis secretory sperm-binding protein Li 199a mRNA, complete cds.
AK128540 - Homo sapiens cDNA FLJ46699 fis, clone TRACH3013700, highly similar to Stress 70 protein chaperonemicrosome-associated 60 kDa protein precursor.
JD245014 - Sequence 226038 from Patent EP1572962.
JD061318 - Sequence 42342 from Patent EP1572962.
JD502074 - Sequence 483098 from Patent EP1572962.
JD507054 - Sequence 488078 from Patent EP1572962.
JD305763 - Sequence 286787 from Patent EP1572962.
LF339692 - JP 2014500723-A/147195: Polycomb-Associated Non-Coding RNAs.
JD228860 - Sequence 209884 from Patent EP1572962.
JD513203 - Sequence 494227 from Patent EP1572962.
LF339693 - JP 2014500723-A/147196: Polycomb-Associated Non-Coding RNAs.
JD559365 - Sequence 540389 from Patent EP1572962.
JD052207 - Sequence 33231 from Patent EP1572962.
JD048024 - Sequence 29048 from Patent EP1572962.
U04735 - Human microsomal stress 70 protein ATPase core (stch) mRNA, complete cds.
AK223282 - Homo sapiens mRNA for stress 70 protein chaperone, microsome-associated, 60kDa precursor variant, clone: SYN06447.
JD500489 - Sequence 481513 from Patent EP1572962.
JD524043 - Sequence 505067 from Patent EP1572962.
JD373436 - Sequence 354460 from Patent EP1572962.
LF339694 - JP 2014500723-A/147197: Polycomb-Associated Non-Coding RNAs.
JD280173 - Sequence 261197 from Patent EP1572962.
JD262321 - Sequence 243345 from Patent EP1572962.
JD273956 - Sequence 254980 from Patent EP1572962.
LF339695 - JP 2014500723-A/147198: Polycomb-Associated Non-Coding RNAs.
JD145677 - Sequence 126701 from Patent EP1572962.
AK299004 - Homo sapiens cDNA FLJ54131 complete cds, highly similar to Stress 70 protein chaperone microsome-associated 60 kDa protein precursor.
JD088670 - Sequence 69694 from Patent EP1572962.
AK312396 - Homo sapiens cDNA, FLJ92728, highly similar to Homo sapiens stress 70 protein chaperone, microsome-associated, 60kDa (STCH), mRNA.
JF432190 - Synthetic construct Homo sapiens clone IMAGE:100073349 heat shock protein 70kDa family, member 13 (STCH) gene, encodes complete protein.
KJ897616 - Synthetic construct Homo sapiens clone ccsbBroadEn_07010 HSPA13 gene, encodes complete protein.
AB384374 - Synthetic construct DNA, clone: pF1KSDB0037, Homo sapiens STCH gene for stress 70 protein chaperone microsome-associated 60 kDa protein precursor, complete cds, without stop codon, in Flexi system.
LF339696 - JP 2014500723-A/147199: Polycomb-Associated Non-Coding RNAs.
LF339697 - JP 2014500723-A/147200: Polycomb-Associated Non-Coding RNAs.
CU690336 - Synthetic construct Homo sapiens gateway clone IMAGE:100019555 5' read STCH mRNA.
LF339698 - JP 2014500723-A/147201: Polycomb-Associated Non-Coding RNAs.
MA446224 - JP 2018138019-A/18150: Polycomb-Associated Non-Coding RNAs.
MA575269 - JP 2018138019-A/147195: Polycomb-Associated Non-Coding RNAs.
MA575270 - JP 2018138019-A/147196: Polycomb-Associated Non-Coding RNAs.
MA575271 - JP 2018138019-A/147197: Polycomb-Associated Non-Coding RNAs.
MA575272 - JP 2018138019-A/147198: Polycomb-Associated Non-Coding RNAs.
MA575273 - JP 2018138019-A/147199: Polycomb-Associated Non-Coding RNAs.
MA575274 - JP 2018138019-A/147200: Polycomb-Associated Non-Coding RNAs.
MA575275 - JP 2018138019-A/147201: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P48723 (Reactome details) participates in the following event(s):

R-HSA-5251942 Hikeshi binds HSP70s:ATP
R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP
R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: B2R616, ENST00000285667.1, ENST00000285667.2, ENST00000285667.3, HSP13_HUMAN, NM_006948, P48723, Q8NE40, STCH, uc317khz.1, uc317khz.2
UCSC ID: ENST00000285667.4_7
RefSeq Accession: NM_006948.5
Protein: P48723 (aka HSP13_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.