The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48723
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF210647 - JP 2014500723-A/18150: Polycomb-Associated Non-Coding RNAs. BC017580 - Homo sapiens, clone IMAGE:4132509, mRNA. BC036370 - Homo sapiens heat shock protein 70kDa family, member 13, mRNA (cDNA clone MGC:26248 IMAGE:4837136), complete cds. HM005612 - Homo sapiens clone HTL-S-199a testis secretory sperm-binding protein Li 199a mRNA, complete cds. AK128540 - Homo sapiens cDNA FLJ46699 fis, clone TRACH3013700, highly similar to Stress 70 protein chaperonemicrosome-associated 60 kDa protein precursor. JD245014 - Sequence 226038 from Patent EP1572962. JD061318 - Sequence 42342 from Patent EP1572962. JD502074 - Sequence 483098 from Patent EP1572962. JD507054 - Sequence 488078 from Patent EP1572962. JD305763 - Sequence 286787 from Patent EP1572962. LF339692 - JP 2014500723-A/147195: Polycomb-Associated Non-Coding RNAs. JD228860 - Sequence 209884 from Patent EP1572962. JD513203 - Sequence 494227 from Patent EP1572962. LF339693 - JP 2014500723-A/147196: Polycomb-Associated Non-Coding RNAs. JD559365 - Sequence 540389 from Patent EP1572962. JD052207 - Sequence 33231 from Patent EP1572962. JD048024 - Sequence 29048 from Patent EP1572962. U04735 - Human microsomal stress 70 protein ATPase core (stch) mRNA, complete cds. AK223282 - Homo sapiens mRNA for stress 70 protein chaperone, microsome-associated, 60kDa precursor variant, clone: SYN06447. JD500489 - Sequence 481513 from Patent EP1572962. JD524043 - Sequence 505067 from Patent EP1572962. JD373436 - Sequence 354460 from Patent EP1572962. LF339694 - JP 2014500723-A/147197: Polycomb-Associated Non-Coding RNAs. JD280173 - Sequence 261197 from Patent EP1572962. JD262321 - Sequence 243345 from Patent EP1572962. JD273956 - Sequence 254980 from Patent EP1572962. LF339695 - JP 2014500723-A/147198: Polycomb-Associated Non-Coding RNAs. JD145677 - Sequence 126701 from Patent EP1572962. AK299004 - Homo sapiens cDNA FLJ54131 complete cds, highly similar to Stress 70 protein chaperone microsome-associated 60 kDa protein precursor. JD088670 - Sequence 69694 from Patent EP1572962. AK312396 - Homo sapiens cDNA, FLJ92728, highly similar to Homo sapiens stress 70 protein chaperone, microsome-associated, 60kDa (STCH), mRNA. JF432190 - Synthetic construct Homo sapiens clone IMAGE:100073349 heat shock protein 70kDa family, member 13 (STCH) gene, encodes complete protein. KJ897616 - Synthetic construct Homo sapiens clone ccsbBroadEn_07010 HSPA13 gene, encodes complete protein. AB384374 - Synthetic construct DNA, clone: pF1KSDB0037, Homo sapiens STCH gene for stress 70 protein chaperone microsome-associated 60 kDa protein precursor, complete cds, without stop codon, in Flexi system. LF339696 - JP 2014500723-A/147199: Polycomb-Associated Non-Coding RNAs. LF339697 - JP 2014500723-A/147200: Polycomb-Associated Non-Coding RNAs. CU690336 - Synthetic construct Homo sapiens gateway clone IMAGE:100019555 5' read STCH mRNA. LF339698 - JP 2014500723-A/147201: Polycomb-Associated Non-Coding RNAs. MA446224 - JP 2018138019-A/18150: Polycomb-Associated Non-Coding RNAs. MA575269 - JP 2018138019-A/147195: Polycomb-Associated Non-Coding RNAs. MA575270 - JP 2018138019-A/147196: Polycomb-Associated Non-Coding RNAs. MA575271 - JP 2018138019-A/147197: Polycomb-Associated Non-Coding RNAs. MA575272 - JP 2018138019-A/147198: Polycomb-Associated Non-Coding RNAs. MA575273 - JP 2018138019-A/147199: Polycomb-Associated Non-Coding RNAs. MA575274 - JP 2018138019-A/147200: Polycomb-Associated Non-Coding RNAs. MA575275 - JP 2018138019-A/147201: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P48723 (Reactome details) participates in the following event(s):
R-HSA-5251942 Hikeshi binds HSP70s:ATP R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli