ID:HXD9_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-D9; AltName: Full=Homeobox protein Hox-4C; AltName: Full=Homeobox protein Hox-5.2; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed in the developing limb buds. SIMILARITY: Belongs to the Abd-B homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. CAUTION: It is uncertain whether Met-1 or Met-11 is the initiator. SEQUENCE CAUTION: Sequence=AAH44855.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA42016.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P28356
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007338 single fertilization GO:0007519 skeletal muscle tissue development GO:0008344 adult locomotory behavior GO:0009952 anterior/posterior pattern specification GO:0009954 proximal/distal pattern formation GO:0010468 regulation of gene expression GO:0030879 mammary gland development GO:0035115 embryonic forelimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048704 embryonic skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048935 peripheral nervous system neuron development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
