ID:HOME1_HUMAN DESCRIPTION: RecName: Full=Homer protein homolog 1; Short=Homer-1; FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. SUBUNIT: Interacts with IFT57 (By similarity). Interacts with OPHN1 (By similarity). Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum (By similarity). DOMAIN: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. SIMILARITY: Belongs to the Homer family. SIMILARITY: Contains 1 WH1 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86YM7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0035256 G-protein coupled glutamate receptor binding GO:0035591 signaling adaptor activity GO:0044325 ion channel binding
Biological Process: GO:0003009 skeletal muscle contraction GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway GO:0007268 chemical synaptic transmission GO:0009967 positive regulation of signal transduction GO:0048148 behavioral response to cocaine GO:0048741 skeletal muscle fiber development GO:0048875 chemical homeostasis within a tissue GO:0051592 response to calcium ion GO:0051928 positive regulation of calcium ion transport GO:0090279 regulation of calcium ion import GO:2001256 regulation of store-operated calcium entry GO:2001257 regulation of cation channel activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
