ID:HNRPL_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein L; Short=hnRNP L; FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. SUBUNIT: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with HNRPLL. Interacts with APEX1; the interaction is DNA-dependent. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. PTM: Several isoelectric forms of the L protein are probably the results of post-translational modifications. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=CAA34261.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14866
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK097975 - Homo sapiens cDNA FLJ40656 fis, clone THYMU2019364, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L. X16135 - Human mRNA for novel heterogeneous nuclear RNP protein, L protein. AK292115 - Homo sapiens cDNA FLJ75895 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRPL), transcript variant 2, mRNA. JD438754 - Sequence 419778 from Patent EP1572962. JD470262 - Sequence 451286 from Patent EP1572962. JD363935 - Sequence 344959 from Patent EP1572962. JD451357 - Sequence 432381 from Patent EP1572962. BC069184 - Homo sapiens heterogeneous nuclear ribonucleoprotein L, mRNA (cDNA clone IMAGE:6174088), partial cds. AB044547 - Homo sapiens P/OKcl.14 mRNA for heterogeneous nuclear ribonucleoprotein L, complete cds. GQ900947 - Homo sapiens clone HEL-T-59 epididymis secretory sperm binding protein mRNA, complete cds. AK092828 - Homo sapiens cDNA FLJ35509 fis, clone SPLEN1000041, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L. AK094966 - Homo sapiens cDNA FLJ37647 fis, clone BRHIP2000445, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L. JD525147 - Sequence 506171 from Patent EP1572962. AK313652 - Homo sapiens cDNA, FLJ94229, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRPL),mRNA. AB587509 - Synthetic construct DNA, clone: pF1KB9904, Homo sapiens HNRNPL gene for heterogeneous nuclear ribonucleoprotein L, without stop codon, in Flexi system. JD239898 - Sequence 220922 from Patent EP1572962. JD232655 - Sequence 213679 from Patent EP1572962. AY927544 - Homo sapiens mRNA sequence. JD041981 - Sequence 23005 from Patent EP1572962. AK301062 - Homo sapiens cDNA FLJ60000 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein L. AK298384 - Homo sapiens cDNA FLJ55127 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein L.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P14866 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
