Human Gene HIC2 (ENST00000407464.7_4) from GENCODE V47lift37

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Description: HIC ZBTB transcriptional repressor 2 (from RefSeq NM_015094.3)
Gencode Transcript: ENST00000407464.7_4
Gencode Gene: ENSG00000169635.10_7
Transcript (Including UTRs)
Position: hg19 chr22:21,771,660-21,805,752 Size: 34,093 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr22:21,797,121-21,801,032 Size: 3,912 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:21,771,660-21,805,752)			mRNA (may differ from genome)		Protein (615 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: HIC2_HUMAN DESCRIPTION: RecName: Full=Hypermethylated in cancer 2 protein; Short=Hic-2; AltName: Full=HIC1-related gene on chromosome 22 protein; AltName: Full=Hic-3; AltName: Full=Zinc finger and BTB domain-containing protein 30; FUNCTION: Transcriptional repressor. SUBUNIT: Self-associates. Interacts with HIC1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highest levels in cerebellum. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 5 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAA82972.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004997 Ethinyl Estradiol C006253 pirinixic acid D000082 Acetaminophen D002922 Ciguatoxins D019327 Copper Sulfate D004147 Dioxins D005472 Fluorouracil D005557 Formaldehyde C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine D013629 Tamoxifen more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.89 RPKM in Testis Total median expression: 83.61 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-139.70	263	-0.531	Picture	PostScript	Text
3' UTR	-1957.60	4720	-0.415	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
54695 - POZ domain
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q96JB3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0008022 protein C-terminus binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045892 negative regulation of transcription, DNA-templated Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AB028943 - Homo sapiens KIAA1020 mRNA for KIAA1020 protein. JD459090 - Sequence 440114 from Patent EP1572962. JD408522 - Sequence 389546 from Patent EP1572962. BC094787 - Homo sapiens hypermethylated in cancer 2, mRNA (cDNA clone MGC:104729 IMAGE:30531041), complete cds. AJ313204 - Homo sapiens mRNA for HRG22 protein. CR456377 - Homo sapiens Em:AP000557.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.Em:AP000557.1.V3). JD091914 - Sequence 72938 from Patent EP1572962. JD406145 - Sequence 387169 from Patent EP1572962. JD389964 - Sequence 370988 from Patent EP1572962. CU013370 - Homo sapiens HIC2, mRNA (cDNA clone IMAGE:100000245), complete cds, without stop codon, in Gateway system. AB384082 - Synthetic construct DNA, clone: pF1KSDA1020, Homo sapiens HIC2 gene for hypermethylated in cancer 2 protein, complete cds, without stop codon, in Flexi system. CU013082 - Homo sapiens HIC2, mRNA (cDNA clone IMAGE:100000341), complete cds, with stop codon, in Gateway system. AF349035 - Homo sapiens HIC-3 mRNA, complete cds. DQ583463 - Homo sapiens piRNA piR-50575, complete sequence. AL162003 - Homo sapiens mRNA; cDNA DKFZp434F0616 (from clone DKFZp434F0616); partial cds. JD125507 - Sequence 106531 from Patent EP1572962. JD078983 - Sequence 60007 from Patent EP1572962. JD535291 - Sequence 516315 from Patent EP1572962. JD392260 - Sequence 373284 from Patent EP1572962. AK023021 - Homo sapiens cDNA FLJ12959 fis, clone NT2RP2005600, highly similar to Homo sapiens mRNA for KIAA1020 protein. JD050992 - Sequence 32016 from Patent EP1572962. JD186309 - Sequence 167333 from Patent EP1572962. JD065062 - Sequence 46086 from Patent EP1572962. JD210282 - Sequence 191306 from Patent EP1572962. JD195118 - Sequence 176142 from Patent EP1572962. JD343667 - Sequence 324691 from Patent EP1572962. JD347111 - Sequence 328135 from Patent EP1572962. JD100727 - Sequence 81751 from Patent EP1572962. JD125097 - Sequence 106121 from Patent EP1572962. JD233120 - Sequence 214144 from Patent EP1572962. JD478394 - Sequence 459418 from Patent EP1572962. JD260730 - Sequence 241754 from Patent EP1572962. JD376519 - Sequence 357543 from Patent EP1572962. JD257963 - Sequence 238987 from Patent EP1572962. JD095527 - Sequence 76551 from Patent EP1572962. JD058566 - Sequence 39590 from Patent EP1572962. JD336202 - Sequence 317226 from Patent EP1572962. JD500415 - Sequence 481439 from Patent EP1572962. JD467904 - Sequence 448928 from Patent EP1572962. JD245445 - Sequence 226469 from Patent EP1572962. JD163783 - Sequence 144807 from Patent EP1572962. JD393534 - Sequence 374558 from Patent EP1572962. JD134148 - Sequence 115172 from Patent EP1572962. BC009207 - Homo sapiens hypermethylated in cancer 2, mRNA (cDNA clone IMAGE:3629289), partial cds. JD283648 - Sequence 264672 from Patent EP1572962. JD147144 - Sequence 128168 from Patent EP1572962. JD090679 - Sequence 71703 from Patent EP1572962. JD186627 - Sequence 167651 from Patent EP1572962. JD080067 - Sequence 61091 from Patent EP1572962. JD385219 - Sequence 366243 from Patent EP1572962. JD404031 - Sequence 385055 from Patent EP1572962. JD322321 - Sequence 303345 from Patent EP1572962. JD221620 - Sequence 202644 from Patent EP1572962. JD496113 - Sequence 477137 from Patent EP1572962. JD220738 - Sequence 201762 from Patent EP1572962. JD223663 - Sequence 204687 from Patent EP1572962. JD533245 - Sequence 514269 from Patent EP1572962. JD387646 - Sequence 368670 from Patent EP1572962. JD118669 - Sequence 99693 from Patent EP1572962. JD179942 - Sequence 160966 from Patent EP1572962. JD156864 - Sequence 137888 from Patent EP1572962. JD389348 - Sequence 370372 from Patent EP1572962. JD503934 - Sequence 484958 from Patent EP1572962. JD147807 - Sequence 128831 from Patent EP1572962. BC009216 - Homo sapiens cDNA clone IMAGE:3842332, partial cds. JD390291 - Sequence 371315 from Patent EP1572962. JD239778 - Sequence 220802 from Patent EP1572962. JD494771 - Sequence 475795 from Patent EP1572962. JD300982 - Sequence 282006 from Patent EP1572962. JD065534 - Sequence 46558 from Patent EP1572962. JD533569 - Sequence 514593 from Patent EP1572962. JD194246 - Sequence 175270 from Patent EP1572962. JD377065 - Sequence 358089 from Patent EP1572962. JD086682 - Sequence 67706 from Patent EP1572962. JD521931 - Sequence 502955 from Patent EP1572962. JD062092 - Sequence 43116 from Patent EP1572962. DQ594544 - Homo sapiens piRNA piR-60656, complete sequence. DQ595866 - Homo sapiens piRNA piR-61978, complete sequence. JD082761 - Sequence 63785 from Patent EP1572962. JD502386 - Sequence 483410 from Patent EP1572962. JD073275 - Sequence 54299 from Patent EP1572962. JD433004 - Sequence 414028 from Patent EP1572962. JD433005 - Sequence 414029 from Patent EP1572962. JD103296 - Sequence 84320 from Patent EP1572962. JD384012 - Sequence 365036 from Patent EP1572962. JD253194 - Sequence 234218 from Patent EP1572962. JD390447 - Sequence 371471 from Patent EP1572962. JD213936 - Sequence 194960 from Patent EP1572962. JD216602 - Sequence 197626 from Patent EP1572962. JD187434 - Sequence 168458 from Patent EP1572962. JD469196 - Sequence 450220 from Patent EP1572962. JD314238 - Sequence 295262 from Patent EP1572962. JD218056 - Sequence 199080 from Patent EP1572962. JD478889 - Sequence 459913 from Patent EP1572962. JD464559 - Sequence 445583 from Patent EP1572962. JD417007 - Sequence 398031 from Patent EP1572962. JD138564 - Sequence 119588 from Patent EP1572962. JD073700 - Sequence 54724 from Patent EP1572962. JD309375 - Sequence 290399 from Patent EP1572962. JD141419 - Sequence 122443 from Patent EP1572962. JD470588 - Sequence 451612 from Patent EP1572962. JD110953 - Sequence 91977 from Patent EP1572962. JD152503 - Sequence 133527 from Patent EP1572962. JD458314 - Sequence 439338 from Patent EP1572962. JD396467 - Sequence 377491 from Patent EP1572962. JD107210 - Sequence 88234 from Patent EP1572962. JD475901 - Sequence 456925 from Patent EP1572962. JD181508 - Sequence 162532 from Patent EP1572962. JD483238 - Sequence 464262 from Patent EP1572962. JD458871 - Sequence 439895 from Patent EP1572962. JD483384 - Sequence 464408 from Patent EP1572962. JD453362 - Sequence 434386 from Patent EP1572962. JD213554 - Sequence 194578 from Patent EP1572962. JD365646 - Sequence 346670 from Patent EP1572962. JD469705 - Sequence 450729 from Patent EP1572962. JD188573 - Sequence 169597 from Patent EP1572962. JD118505 - Sequence 99529 from Patent EP1572962. JD445413 - Sequence 426437 from Patent EP1572962. JD470672 - Sequence 451696 from Patent EP1572962. JD439634 - Sequence 420658 from Patent EP1572962. JD492112 - Sequence 473136 from Patent EP1572962. JD132245 - Sequence 113269 from Patent EP1572962. JD367995 - Sequence 349019 from Patent EP1572962. JD060562 - Sequence 41586 from Patent EP1572962. JD484132 - Sequence 465156 from Patent EP1572962. JD504059 - Sequence 485083 from Patent EP1572962. JD382086 - Sequence 363110 from Patent EP1572962. JD248265 - Sequence 229289 from Patent EP1572962. JD368632 - Sequence 349656 from Patent EP1572962. JD371827 - Sequence 352851 from Patent EP1572962. JD450604 - Sequence 431628 from Patent EP1572962. JD448690 - Sequence 429714 from Patent EP1572962. JD171049 - Sequence 152073 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000407464.1, ENST00000407464.2, ENST00000407464.3, ENST00000407464.4, ENST00000407464.5, ENST00000407464.6, HIC2_HUMAN, HRG22, KIAA1020, NM_015094, Q504T6, Q96JB3, Q96KR3, Q9NSM9, Q9UPX9, uc319dwr.1, uc319dwr.2, ZBTB30 UCSC ID: ENST00000407464.7_4 RefSeq Accession: NM_015094.3 Protein: Q96JB3 (aka HIC2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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