Human Gene TAMALIN (ENST00000293662.9_4) from GENCODE V47lift37
  Description: trafficking regulator and scaffold protein tamalin, transcript variant 1 (from RefSeq NM_181711.4)
Gencode Transcript: ENST00000293662.9_4
Gencode Gene: ENSG00000161835.11_10
Transcript (Including UTRs)
   Position: hg19 chr12:52,400,730-52,409,673 Size: 8,944 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr12:52,400,804-52,408,983 Size: 8,180 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:52,400,730-52,409,673)mRNA (may differ from genome)Protein (395 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GRASP_HUMAN
DESCRIPTION: RecName: Full=General receptor for phosphoinositides 1-associated scaffold protein; Short=GRP1-associated scaffold protein;
FUNCTION: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses (By similarity).
SUBUNIT: Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Localized at postsynaptic membranes (By similarity).
SIMILARITY: Contains 1 PDZ (DHR) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.24 RPKM in Lung
Total median expression: 651.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.8074-0.484 Picture PostScript Text
3' UTR -311.60690-0.452 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001478 - PDZ

Pfam Domains:
PF00595 - PDZ domain
PF17820 - PDZ domain

SCOP Domains:
50156 - PDZ domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2PNT - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q7Z6J2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030165 PDZ domain binding
GO:0030306 ADP-ribosylation factor binding
GO:0042802 identical protein binding

Biological Process:
GO:0007165 signal transduction
GO:0008104 protein localization

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF210459 - JP 2014500723-A/17962: Polycomb-Associated Non-Coding RNAs.
LF338045 - JP 2014500723-A/145548: Polycomb-Associated Non-Coding RNAs.
BC053666 - Homo sapiens GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein, mRNA (cDNA clone MGC:61601 IMAGE:6151168), complete cds.
BC052967 - Homo sapiens GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein, mRNA (cDNA clone IMAGE:5588584), partial cds.
JD213520 - Sequence 194544 from Patent EP1572962.
BC035500 - Homo sapiens GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein, mRNA (cDNA clone MGC:20836 IMAGE:4422992), complete cds.
JD408167 - Sequence 389191 from Patent EP1572962.
LF338049 - JP 2014500723-A/145552: Polycomb-Associated Non-Coding RNAs.
JD217681 - Sequence 198705 from Patent EP1572962.
AJ227899 - Homo sapiens partial mRNA; ID EE2-12A.
JD138527 - Sequence 119551 from Patent EP1572962.
JD123821 - Sequence 104845 from Patent EP1572962.
JD484655 - Sequence 465679 from Patent EP1572962.
JD277217 - Sequence 258241 from Patent EP1572962.
JD411318 - Sequence 392342 from Patent EP1572962.
JD498822 - Sequence 479846 from Patent EP1572962.
JD085589 - Sequence 66613 from Patent EP1572962.
JD117987 - Sequence 99011 from Patent EP1572962.
JD547119 - Sequence 528143 from Patent EP1572962.
JD436907 - Sequence 417931 from Patent EP1572962.
JD403406 - Sequence 384430 from Patent EP1572962.
LF338050 - JP 2014500723-A/145553: Polycomb-Associated Non-Coding RNAs.
JD222421 - Sequence 203445 from Patent EP1572962.
JD080040 - Sequence 61064 from Patent EP1572962.
JD394288 - Sequence 375312 from Patent EP1572962.
JD435677 - Sequence 416701 from Patent EP1572962.
MA446036 - JP 2018138019-A/17962: Polycomb-Associated Non-Coding RNAs.
MA573622 - JP 2018138019-A/145548: Polycomb-Associated Non-Coding RNAs.
MA573626 - JP 2018138019-A/145552: Polycomb-Associated Non-Coding RNAs.
MA573627 - JP 2018138019-A/145553: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000293662.1, ENST00000293662.2, ENST00000293662.3, ENST00000293662.4, ENST00000293662.5, ENST00000293662.6, ENST00000293662.7, ENST00000293662.8, GRASP, GRASP_HUMAN, NM_181711, Q6PIF8, Q7Z6J2, Q7Z741, TAMALIN , uc317leg.1, uc317leg.2
UCSC ID: ENST00000293662.9_4
RefSeq Accession: NM_181711.4
Protein: Q7Z6J2 (aka GRASP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.