Human Gene GOLGA7 (ENST00000357743.9_4) from GENCODE V47lift37
  Description: golgin A7, transcript variant 1 (from RefSeq NM_016099.3)
Gencode Transcript: ENST00000357743.9_4
Gencode Gene: ENSG00000147533.19_12
Transcript (Including UTRs)
   Position: hg19 chr8:41,348,101-41,368,499 Size: 20,399 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr8:41,348,374-41,364,625 Size: 16,252 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:41,348,101-41,368,499)mRNA (may differ from genome)Protein (137 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GOGA7_HUMAN
DESCRIPTION: RecName: Full=Golgin subfamily A member 7; AltName: Full=Golgi complex-associated protein of 16 kDa;
FUNCTION: May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
SUBUNIT: Interacts with GOLGA3. Interacts with ZDHHC9.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
TISSUE SPECIFICITY: Expressed in all tissues except colon and thymus.
PTM: Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.
SIMILARITY: Belongs to the ERF4 family.
SEQUENCE CAUTION: Sequence=AAD39919.1; Type=Frameshift; Positions=36; Sequence=AAF65180.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.26 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 1081.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.00273-0.542 Picture PostScript Text
3' UTR -332.711412-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019383 - Golgin_A_7/ERF4

Pfam Domains:
PF10256 - Golgin subfamily A member 7/ERF4 family

ModBase Predicted Comparative 3D Structure on Q7Z5G4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0006612 protein targeting to membrane
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0043001 Golgi to plasma membrane protein transport
GO:0043312 neutrophil degranulation
GO:0050821 protein stabilization

Cellular Component:
GO:0000139 Golgi membrane
GO:0002178 palmitoyltransferase complex
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0031228 intrinsic component of Golgi membrane
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen


-  Descriptions from all associated GenBank mRNAs
  LF208053 - JP 2014500723-A/15556: Polycomb-Associated Non-Coding RNAs.
AK026613 - Homo sapiens cDNA: FLJ22960 fis, clone KAT10193, highly similar to AF125102 Homo sapiens HSPC041 protein mRNA.
AB104615 - Homo sapiens gcp16 mRNA for Golgi complex-associated protein of 16kDa, complete cds.
BC001227 - Homo sapiens golgi autoantigen, golgin subfamily a, 7, mRNA (cDNA clone IMAGE:3456384), containing frame-shift errors.
JD071758 - Sequence 52782 from Patent EP1572962.
AF125102 - Homo sapiens HSPC041 protein mRNA, complete cds.
AF068291 - Homo sapiens HDCKB03P mRNA, partial cds.
BC012032 - Homo sapiens golgi autoantigen, golgin subfamily a, 7, mRNA (cDNA clone MGC:21096 IMAGE:4707385), complete cds.
LF371667 - JP 2014500723-A/179170: Polycomb-Associated Non-Coding RNAs.
KJ893827 - Synthetic construct Homo sapiens clone ccsbBroadEn_03221 GOLGA7 gene, encodes complete protein.
KJ898831 - Synthetic construct Homo sapiens clone ccsbBroadEn_08225 GOLGA7 gene, encodes complete protein.
LF371660 - JP 2014500723-A/179163: Polycomb-Associated Non-Coding RNAs.
JD525164 - Sequence 506188 from Patent EP1572962.
LF371659 - JP 2014500723-A/179162: Polycomb-Associated Non-Coding RNAs.
JD350022 - Sequence 331046 from Patent EP1572962.
JD489649 - Sequence 470673 from Patent EP1572962.
JD288626 - Sequence 269650 from Patent EP1572962.
JD142952 - Sequence 123976 from Patent EP1572962.
JD091101 - Sequence 72125 from Patent EP1572962.
LF371658 - JP 2014500723-A/179161: Polycomb-Associated Non-Coding RNAs.
LF371657 - JP 2014500723-A/179160: Polycomb-Associated Non-Coding RNAs.
JD299671 - Sequence 280695 from Patent EP1572962.
JD500012 - Sequence 481036 from Patent EP1572962.
JD512343 - Sequence 493367 from Patent EP1572962.
LF371656 - JP 2014500723-A/179159: Polycomb-Associated Non-Coding RNAs.
JD280409 - Sequence 261433 from Patent EP1572962.
JD479988 - Sequence 461012 from Patent EP1572962.
JD403432 - Sequence 384456 from Patent EP1572962.
LF371655 - JP 2014500723-A/179158: Polycomb-Associated Non-Coding RNAs.
LF371654 - JP 2014500723-A/179157: Polycomb-Associated Non-Coding RNAs.
JD232705 - Sequence 213729 from Patent EP1572962.
MA607244 - JP 2018138019-A/179170: Polycomb-Associated Non-Coding RNAs.
MA607237 - JP 2018138019-A/179163: Polycomb-Associated Non-Coding RNAs.
MA607236 - JP 2018138019-A/179162: Polycomb-Associated Non-Coding RNAs.
MA607235 - JP 2018138019-A/179161: Polycomb-Associated Non-Coding RNAs.
MA607234 - JP 2018138019-A/179160: Polycomb-Associated Non-Coding RNAs.
MA607233 - JP 2018138019-A/179159: Polycomb-Associated Non-Coding RNAs.
MA607232 - JP 2018138019-A/179158: Polycomb-Associated Non-Coding RNAs.
MA607231 - JP 2018138019-A/179157: Polycomb-Associated Non-Coding RNAs.
MA443630 - JP 2018138019-A/15556: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z5G4 (Reactome details) participates in the following event(s):

R-HSA-6798745 Exocytosis of tertiary granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: D3DSX9, ENST00000357743.1, ENST00000357743.2, ENST00000357743.3, ENST00000357743.4, ENST00000357743.5, ENST00000357743.6, ENST00000357743.7, ENST00000357743.8, GCP16, GOGA7_HUMAN, HDCKB03P, HSPC041, J3KQ24, NM_016099, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7, uc318afc.1, uc318afc.2
UCSC ID: ENST00000357743.9_4
RefSeq Accession: NM_001002296.2
Protein: Q7Z5G4 (aka GOGA7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.