Human Gene GID4 (ENST00000268719.9_4) from GENCODE V47lift37
  Description: GID complex subunit 4 homolog (from RefSeq NM_024052.5)
Gencode Transcript: ENST00000268719.9_4
Gencode Gene: ENSG00000141034.10_10
Transcript (Including UTRs)
   Position: hg19 chr17:17,942,722-17,971,719 Size: 28,998 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr17:17,942,779-17,968,557 Size: 25,779 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:17,942,722-17,971,719)mRNA (may differ from genome)Protein (300 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GID4_HUMAN
DESCRIPTION: RecName: Full=Glucose-induced degradation protein 4 homolog; AltName: Full=Vacuolar import and degradation protein 24 homolog;
SIMILARITY: Belongs to the GID4/VID24 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GID4
Diseases sorted by gene-association score: smith-magenis syndrome (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.13 RPKM in Testis
Total median expression: 224.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00570.000 Picture PostScript Text
3' UTR -976.403162-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018618 - Vacuolar_import/degrad_Vid24

Pfam Domains:
PF09783 - Vacuolar import and degradation protein

ModBase Predicted Comparative 3D Structure on Q8IVV7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process


-  Descriptions from all associated GenBank mRNAs
  BC041829 - Homo sapiens chromosome 17 open reading frame 39, mRNA (cDNA clone MGC:43491 IMAGE:5268071), complete cds.
AK315083 - Homo sapiens cDNA, FLJ96039.
AK074284 - Homo sapiens cDNA FLJ23704 fis, clone HEP10851.
AK127580 - Homo sapiens cDNA FLJ45675 fis, clone DFNES2001829.
BC000636 - Homo sapiens chromosome 17 open reading frame 39, mRNA (cDNA clone IMAGE:3343305), partial cds.
JD314979 - Sequence 296003 from Patent EP1572962.
JD221730 - Sequence 202754 from Patent EP1572962.
JD038411 - Sequence 19435 from Patent EP1572962.
JD503604 - Sequence 484628 from Patent EP1572962.
JD210717 - Sequence 191741 from Patent EP1572962.
JD396878 - Sequence 377902 from Patent EP1572962.
JD484492 - Sequence 465516 from Patent EP1572962.
JD445472 - Sequence 426496 from Patent EP1572962.
JD205586 - Sequence 186610 from Patent EP1572962.
JD080572 - Sequence 61596 from Patent EP1572962.
JD494451 - Sequence 475475 from Patent EP1572962.
JD289428 - Sequence 270452 from Patent EP1572962.
JD281841 - Sequence 262865 from Patent EP1572962.
JD375236 - Sequence 356260 from Patent EP1572962.
JD218272 - Sequence 199296 from Patent EP1572962.
JD163355 - Sequence 144379 from Patent EP1572962.
JD400847 - Sequence 381871 from Patent EP1572962.
JD316031 - Sequence 297055 from Patent EP1572962.
JD305829 - Sequence 286853 from Patent EP1572962.
AK124377 - Homo sapiens cDNA FLJ42386 fis, clone UTERU2037674.

-  Other Names for This Gene
  Alternate Gene Symbols: C17orf39, ENST00000268719.1, ENST00000268719.2, ENST00000268719.3, ENST00000268719.4, ENST00000268719.5, ENST00000268719.6, ENST00000268719.7, ENST00000268719.8, GID4_HUMAN, NM_024052, Q8IVV7, Q8TEB5, Q9BW50, uc317ioq.1, uc317ioq.2, VID24
UCSC ID: ENST00000268719.9_4
RefSeq Accession: NM_024052.5
Protein: Q8IVV7 (aka GID4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.