ID:GGA2_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor-binding protein GGA2; AltName: Full=Gamma-adaptin-related protein 2; AltName: Full=Golgi-localized, gamma ear-containing, ARF-binding protein 2; AltName: Full=VHS domain and ear domain of gamma-adaptin; Short=Vear; FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. SUBUNIT: Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2. INTERACTION: Q15276:RABEP1; NbExp=6; IntAct=EBI-447646, EBI-447043; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif). DOMAIN: The GAT domain is responsible for interaction with ARF- GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis. DOMAIN: The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs. DOMAIN: The GAE domain binds accessory proteins regulating GGAs function. PTM: Ubiquitinated (By similarity). SIMILARITY: Belongs to the GGA protein family. SIMILARITY: Contains 1 GAE domain. SIMILARITY: Contains 1 GAT domain. SIMILARITY: Contains 1 VHS domain. SEQUENCE CAUTION: Sequence=AAK38634.1; Type=Frameshift; Positions=193;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UJY4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0030306 ADP-ribosylation factor binding
Biological Process: GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0044267 cellular protein metabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
