Human Gene GCGR (ENST00000400723.8_4) from GENCODE V47lift37
  Description: glucagon receptor (from RefSeq NM_000160.5)
Gencode Transcript: ENST00000400723.8_4
Gencode Gene: ENSG00000215644.10_10
Transcript (Including UTRs)
   Position: hg19 chr17:79,762,026-79,771,884 Size: 9,859 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr17:79,766,895-79,771,565 Size: 4,671 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:79,762,026-79,771,884)mRNA (may differ from genome)Protein (477 aa)
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UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GLR_HUMAN
DESCRIPTION: RecName: Full=Glucagon receptor; Short=GL-R; Flags: Precursor;
FUNCTION: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GCGR
Diseases sorted by gene-association score: gcgr-related hyperglucagonemia* (350), diabetes mellitus, noninsulin-dependent* (341), hyperglycemia (4), hypertension, essential (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 67.78 RPKM in Liver
Total median expression: 96.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -122.70277-0.443 Picture PostScript Text
3' UTR -149.40319-0.468 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR003290 - GPCR_2_GLP1/glucagon_rcpt
IPR003291 - GPCR_2_glucagon_rcpt
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF02793 - Hormone receptor domain

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3CZF - X-ray 4ERS - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P47871
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004967 glucagon receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0017046 peptide hormone binding

Biological Process:
GO:0006091 generation of precursor metabolites and energy
GO:0006887 exocytosis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008217 regulation of blood pressure
GO:0009755 hormone-mediated signaling pathway
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0070873 regulation of glycogen metabolic process
GO:0071377 cellular response to glucagon stimulus

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK307234 - Homo sapiens cDNA, FLJ97182.
AK314247 - Homo sapiens cDNA, FLJ94992.
L20316 - Human glucagon receptor mRNA, complete cds.
JD483293 - Sequence 464317 from Patent EP1572962.
JD386711 - Sequence 367735 from Patent EP1572962.
JD203552 - Sequence 184576 from Patent EP1572962.
U03469 - Human glucagon receptor mRNA, complete cds.
JD270702 - Sequence 251726 from Patent EP1572962.
JD122382 - Sequence 103406 from Patent EP1572962.
BC104854 - Homo sapiens glucagon receptor, mRNA (cDNA clone MGC:132514 IMAGE:8143857), complete cds.
BC112041 - Homo sapiens glucagon receptor, mRNA (cDNA clone MGC:138246 IMAGE:8327509), complete cds.
JD481151 - Sequence 462175 from Patent EP1572962.
KJ891228 - Synthetic construct Homo sapiens clone ccsbBroadEn_00622 GCGR gene, encodes complete protein.
JD057231 - Sequence 38255 from Patent EP1572962.
JD054621 - Sequence 35645 from Patent EP1572962.
JD392615 - Sequence 373639 from Patent EP1572962.
JD078935 - Sequence 59959 from Patent EP1572962.
JD281880 - Sequence 262904 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P47871 (Reactome details) participates in the following event(s):

R-HSA-163625 Glucagon binds to Glucagon receptor
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-825631 Glucagon:GCGR mediates GTP-GDP exchange
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-163685 Energy Metabolism
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-1430728 Metabolism
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000400723.1, ENST00000400723.2, ENST00000400723.3, ENST00000400723.4, ENST00000400723.5, ENST00000400723.6, ENST00000400723.7, GLR_HUMAN, NM_000160, P47871, Q2M3M5, uc319azm.1, uc319azm.2
UCSC ID: ENST00000400723.8_4
RefSeq Accession: NM_000160.5
Protein: P47871 (aka GLR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.