ID:GABR2_HUMAN DESCRIPTION: RecName: Full=Gamma-aminobutyric acid type B receptor subunit 2; Short=GABA-B receptor 2; Short=GABA-B-R2; Short=GABA-BR2; Short=GABABR2; Short=Gb2; AltName: Full=G-protein coupled receptor 51; AltName: Full=HG20; Flags: Precursor; FUNCTION: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. TISSUE SPECIFICITY: Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. DOMAIN: Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. SEQUENCE CAUTION: Sequence=AAH35071.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75899
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF056085 - Homo sapiens GABA-B receptor mRNA, complete cds. AF099033 - Homo sapiens gamma-aminobutyric acid type B receptor 2 (GABABR2) mRNA, complete cds. BC035071 - Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 2, mRNA (cDNA clone MGC:43091 IMAGE:5260138), complete cds. AF095784 - Homo sapiens GABA-B receptor R2 (GABBR2) mRNA, complete cds. AF069755 - Homo sapiens orphan G protein-coupled receptor HG20 (HG20) mRNA, complete cds. AF074483 - Homo sapiens GABA-B receptor 2 mRNA, complete cds. AJ012188 - Homo sapiens mRNA for GABAB receptor, subunit 2. JQ308173 - Homo sapiens gamma-aminobutyric acid B receptor 2 mRNA, complete cds. DQ891731 - Synthetic construct clone IMAGE:100004361; FLH179488.01X; RZPDo839H01130D gamma-aminobutyric acid (GABA) B receptor, 2 (GABBR2) gene, encodes complete protein. KJ901996 - Synthetic construct Homo sapiens clone ccsbBroadEn_11390 GABBR2 gene, encodes complete protein. AK308139 - Homo sapiens cDNA, FLJ98087. DQ894908 - Synthetic construct Homo sapiens clone IMAGE:100009368; FLH179484.01L; RZPDo839H01129D gamma-aminobutyric acid (GABA) B receptor, 2 (GABBR2) gene, encodes complete protein. AB384741 - Synthetic construct DNA, clone: pF1KB3078, Homo sapiens GABBR2 gene for gamma-aminobutyric-acid type B receptor, subunit 2 precursor, complete cds, without stop codon, in Flexi system. CU690042 - Synthetic construct Homo sapiens gateway clone IMAGE:100017829 5' read GABBR2 mRNA. BC055425 - Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 2, mRNA (cDNA clone IMAGE:5263781). BC031317 - Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 2, mRNA (cDNA clone IMAGE:5277497). AB015334 - Homo sapiens HRIHFB2099 mRNA, partial cds. JD470336 - Sequence 451360 from Patent EP1572962. JD477488 - Sequence 458512 from Patent EP1572962. JD458477 - Sequence 439501 from Patent EP1572962. JD458497 - Sequence 439521 from Patent EP1572962. JD458496 - Sequence 439520 from Patent EP1572962. JD458495 - Sequence 439519 from Patent EP1572962. JD271289 - Sequence 252313 from Patent EP1572962. JD458507 - Sequence 439531 from Patent EP1572962. JD458520 - Sequence 439544 from Patent EP1572962. JD200353 - Sequence 181377 from Patent EP1572962. JD200351 - Sequence 181375 from Patent EP1572962. JD462061 - Sequence 443085 from Patent EP1572962. JD056235 - Sequence 37259 from Patent EP1572962. JD458584 - Sequence 439608 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75899 (Reactome details) participates in the following event(s):
R-HSA-420688 GABAB heterodimeric receptor binds GABA R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-1013020 Activation of GIRK/Kir3 Channels R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-977444 GABA B receptor activation R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-977443 GABA receptor activation R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-162582 Signal Transduction R-HSA-112315 Transmission across Chemical Synapses R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-1296041 Activation of G protein gated Potassium channels R-HSA-112316 Neuronal System R-HSA-991365 Activation of GABAB receptors R-HSA-1296059 G protein gated Potassium channels R-HSA-1296065 Inwardly rectifying K+ channels R-HSA-1296071 Potassium Channels
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
