Human Gene FBXO46 (ENST00000317683.4_7) from GENCODE V47lift37
  Description: F-box protein 46, transcript variant 4 (from RefSeq NM_001329634.1)
Gencode Transcript: ENST00000317683.4_7
Gencode Gene: ENSG00000177051.6_12
Transcript (Including UTRs)
   Position: hg19 chr19:46,213,887-46,234,154 Size: 20,268 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:46,214,942-46,216,753 Size: 1,812 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:46,213,887-46,234,154)mRNA (may differ from genome)Protein (603 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FBX46_HUMAN
DESCRIPTION: RecName: Full=F-box only protein 46; AltName: Full=F-box only protein 34-like;
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity).
SUBUNIT: Interacts with SKP1 and CUL1 (By similarity).
INTERACTION: P63208:SKP1; NbExp=3; IntAct=EBI-2322982, EBI-307486;
SIMILARITY: Contains 1 F-box domain.
CAUTION: The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse sequence.
SEQUENCE CAUTION: Sequence=AAH21978.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH21978.1; Type=Erroneous termination; Positions=604; Note=Translated as stop;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.67 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 294.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.20126-0.383 Picture PostScript Text
3' UTR -361.701055-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001810 - F-box_dom_cyclin-like

Pfam Domains:
PF00646 - F-box domain
PF12937 - F-box-like

SCOP Domains:
81383 - F-box domain

ModBase Predicted Comparative 3D Structure on Q6PJ61
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  BC013570 - Homo sapiens F-box protein 46, mRNA (cDNA clone IMAGE:3893784), with apparent retained intron.
BC046245 - Homo sapiens, Similar to RIKEN cDNA 4932704E22 gene, clone IMAGE:5587686, mRNA.
BC008046 - Homo sapiens cDNA clone IMAGE:3615905, containing frame-shift errors.
Y10936 - H.sapiens mRNA for hypothetical protein downstream of DMPK and DMAHP.
JD527143 - Sequence 508167 from Patent EP1572962.
JD565828 - Sequence 546852 from Patent EP1572962.
JD150245 - Sequence 131269 from Patent EP1572962.
JD228492 - Sequence 209516 from Patent EP1572962.
JD163315 - Sequence 144339 from Patent EP1572962.
JD298649 - Sequence 279673 from Patent EP1572962.
JD144412 - Sequence 125436 from Patent EP1572962.
JD241176 - Sequence 222200 from Patent EP1572962.
JD093340 - Sequence 74364 from Patent EP1572962.
JD553656 - Sequence 534680 from Patent EP1572962.
JD126255 - Sequence 107279 from Patent EP1572962.
BC021978 - Homo sapiens F-box protein 46, mRNA (cDNA clone MGC:16495 IMAGE:3957915), complete cds.
DQ584225 - Homo sapiens piRNA piR-51337, complete sequence.
JD134948 - Sequence 115972 from Patent EP1572962.
JD104400 - Sequence 85424 from Patent EP1572962.
JD108677 - Sequence 89701 from Patent EP1572962.
KJ904689 - Synthetic construct Homo sapiens clone ccsbBroadEn_14083 FBXO46-like gene, encodes complete protein.
JD335135 - Sequence 316159 from Patent EP1572962.
DL491872 - Novel nucleic acids.
DL490437 - Novel nucleic acids.
CU692434 - Synthetic construct Homo sapiens gateway clone IMAGE:100022467 5' read FBXO46 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000317683.1, ENST00000317683.2, ENST00000317683.3, FBX46, FBX46_HUMAN, FBXO34L, NM_001329634, Q6PJ61, uc317qho.1, uc317qho.2
UCSC ID: ENST00000317683.4_7
RefSeq Accession: NM_001080469.2
Protein: Q6PJ61 (aka FBX46_HUMAN or FX46_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.