Human Gene FBXO17 (ENST00000292852.9_7) from GENCODE V47lift37

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Description: F-box protein 17, transcript variant 3 (from RefSeq NR_104026.2)
Gencode Transcript: ENST00000292852.9_7
Gencode Gene: ENSG00000269190.6_13
Transcript (Including UTRs)
Position: hg19 chr19:39,432,041-39,466,382 Size: 34,342 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr19:39,433,248-39,440,959 Size: 7,712 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:39,432,041-39,466,382)			mRNA (may differ from genome)		Protein (278 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: FBX17_HUMAN DESCRIPTION: RecName: Full=F-box only protein 17; AltName: Full=F-box only protein 26; FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex- type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins. SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 1 FBA (F-box associated) domain. SEQUENCE CAUTION: Sequence=BAB71616.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D000535 Aluminum D011794 Quercetin D012643 Selenium D014810 Vitamin E

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.74 RPKM in Ovary Total median expression: 189.80 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-72.00	174	-0.414	Picture	PostScript	Text
3' UTR	-416.70	1207	-0.345	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007397 - F-box-assoc_dom
IPR001810 - F-box_dom_cyclin-like
IPR008979 - Galactose-bd-like

Pfam Domains:
PF00646 - F-box domain
PF04300 - F-box associated region
PF12937 - F-box-like

SCOP Domains:
81383 - F-box domain
49785 - Galactose-binding domain-like

ModBase Predicted Comparative 3D Structure on Q96EF6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding Biological Process: GO:0000209 protein polyubiquitination GO:0043687 post-translational protein modification Cellular Component: GO:0005829 cytosol GO:0019005 SCF ubiquitin ligase complex

Descriptions from all associated GenBank mRNAs


	AF386743 - Homo sapiens F-box protein (FBG4) mRNA, complete cds. BC012385 - Homo sapiens F-box protein 17, mRNA (cDNA clone MGC:9379 IMAGE:3864760), complete cds. AK301903 - Homo sapiens cDNA FLJ58300 complete cds, highly similar to Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11). JD304413 - Sequence 285437 from Patent EP1572962. JD236435 - Sequence 217459 from Patent EP1572962. JD320183 - Sequence 301207 from Patent EP1572962. JD234669 - Sequence 215693 from Patent EP1572962. JD179229 - Sequence 160253 from Patent EP1572962. JD421605 - Sequence 402629 from Patent EP1572962. JD271218 - Sequence 252242 from Patent EP1572962. JD206963 - Sequence 187987 from Patent EP1572962. JD500683 - Sequence 481707 from Patent EP1572962. JD438376 - Sequence 419400 from Patent EP1572962. JD334582 - Sequence 315606 from Patent EP1572962. JD535346 - Sequence 516370 from Patent EP1572962. JD309992 - Sequence 291016 from Patent EP1572962. JD439188 - Sequence 420212 from Patent EP1572962. AK226156 - Homo sapiens mRNA for Hypothetical protein FLJ11798 variant, clone: sj05062. AK021860 - Homo sapiens cDNA FLJ11798 fis, clone HEMBA1006198. AK057934 - Homo sapiens cDNA FLJ25205 fis, clone REC05844, highly similar to Mus musculus F-box protein FBX17 mRNA. JD518054 - Sequence 499078 from Patent EP1572962. JD366738 - Sequence 347762 from Patent EP1572962. JD518053 - Sequence 499077 from Patent EP1572962. JD093697 - Sequence 74721 from Patent EP1572962. JD184337 - Sequence 165361 from Patent EP1572962. JD268551 - Sequence 249575 from Patent EP1572962. JD229266 - Sequence 210290 from Patent EP1572962. JD143904 - Sequence 124928 from Patent EP1572962. JD396750 - Sequence 377774 from Patent EP1572962. JD445085 - Sequence 426109 from Patent EP1572962. JD439199 - Sequence 420223 from Patent EP1572962. JD329244 - Sequence 310268 from Patent EP1572962. JD134015 - Sequence 115039 from Patent EP1572962. JD193635 - Sequence 174659 from Patent EP1572962. JD536958 - Sequence 517982 from Patent EP1572962. JD293823 - Sequence 274847 from Patent EP1572962. JD092271 - Sequence 73295 from Patent EP1572962. JD207906 - Sequence 188930 from Patent EP1572962. JD481098 - Sequence 462122 from Patent EP1572962. JD294777 - Sequence 275801 from Patent EP1572962. JD472738 - Sequence 453762 from Patent EP1572962. JD472737 - Sequence 453761 from Patent EP1572962. JD079502 - Sequence 60526 from Patent EP1572962. JD160531 - Sequence 141555 from Patent EP1572962. JD458648 - Sequence 439672 from Patent EP1572962. JD546400 - Sequence 527424 from Patent EP1572962. JD546399 - Sequence 527423 from Patent EP1572962. JD425316 - Sequence 406340 from Patent EP1572962. JD139155 - Sequence 120179 from Patent EP1572962. JD171557 - Sequence 152581 from Patent EP1572962. JD238079 - Sequence 219103 from Patent EP1572962. JD051244 - Sequence 32268 from Patent EP1572962. JD512858 - Sequence 493882 from Patent EP1572962. JD412871 - Sequence 393895 from Patent EP1572962. JD376008 - Sequence 357032 from Patent EP1572962. JD536174 - Sequence 517198 from Patent EP1572962. JD117352 - Sequence 98376 from Patent EP1572962. JD319675 - Sequence 300699 from Patent EP1572962. JD329224 - Sequence 310248 from Patent EP1572962. JD491639 - Sequence 472663 from Patent EP1572962. JD056693 - Sequence 37717 from Patent EP1572962. DQ891329 - Synthetic construct clone IMAGE:100003959; FLH171133.01X; RZPDo839F06100D F-box protein 17 (FBXO17) gene, encodes complete protein. DQ893357 - Synthetic construct clone IMAGE:100005987; FLH196565.01X; RZPDo839E11156D F-box protein 17 (FBXO17) gene, encodes complete protein. KJ900021 - Synthetic construct Homo sapiens clone ccsbBroadEn_09415 FBXO17 gene, encodes complete protein. DQ894512 - Synthetic construct Homo sapiens clone IMAGE:100008972; FLH171129.01L; RZPDo839F0699D F-box protein 17 (FBXO17) gene, encodes complete protein. DQ896676 - Synthetic construct Homo sapiens clone IMAGE:100011136; FLH196561.01L; RZPDo839E11155D F-box protein 17 (FBXO17) gene, encodes complete protein. JD129127 - Sequence 110151 from Patent EP1572962. JD536721 - Sequence 517745 from Patent EP1572962. JD139355 - Sequence 120379 from Patent EP1572962. JD226628 - Sequence 207652 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q96EF6 (Reactome details) participates in the following event(s): R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex R-HSA-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-HSA-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-8951664 Neddylation R-HSA-1280218 Adaptive Immune System R-HSA-597592 Post-translational protein modification R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: ENST00000292852.1, ENST00000292852.2, ENST00000292852.3, ENST00000292852.4, ENST00000292852.5, ENST00000292852.6, ENST00000292852.7, ENST00000292852.8, FBG4, FBX17, FBX17_HUMAN, FBX26, FBXO26, NR_104026, Q96EF6, Q96LQ4, uc317lco.1, uc317lco.2 UCSC ID: ENST00000292852.9_7 RefSeq Accession: NM_024907.7 Protein: Q96EF6 (aka FBX17_HUMAN or FX17_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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