Human Gene FBXO16 (ENST00000380254.7_10) from GENCODE V47lift37
  Description: F-box protein 16, transcript variant 1 (from RefSeq NM_172366.4)
Gencode Transcript: ENST00000380254.7_10
Gencode Gene: ENSG00000214050.8_16
Transcript (Including UTRs)
   Position: hg19 chr8:28,285,929-28,347,746 Size: 61,818 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr8:28,286,244-28,340,963 Size: 54,720 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:28,285,929-28,347,746)mRNA (may differ from genome)Protein (292 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FBX16_HUMAN
DESCRIPTION: RecName: Full=F-box only protein 16;
FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
TISSUE SPECIFICITY: Expressed in heart, spleen and colon.
SIMILARITY: Contains 1 F-box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.00 RPKM in Pituitary
Total median expression: 73.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.5060-0.158 Picture PostScript Text
3' UTR -83.10315-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001810 - F-box_dom_cyclin-like

Pfam Domains:
PF00646 - F-box domain
PF12937 - F-box-like

SCOP Domains:
81383 - F-box domain

ModBase Predicted Comparative 3D Structure on Q8IX29
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  AK098243 - Homo sapiens cDNA FLJ40924 fis, clone UTERU2006429, highly similar to Zinc finger protein 395.
AF453435 - Homo sapiens F-box protein 16 (FBX16) mRNA, complete cds.
BC102026 - Homo sapiens F-box protein 16, mRNA (cDNA clone MGC:125925 IMAGE:40031445), complete cds.
BC102027 - Homo sapiens F-box protein 16, mRNA (cDNA clone MGC:125924 IMAGE:40031444), complete cds.
BC102028 - Homo sapiens F-box protein 16, mRNA (cDNA clone MGC:125923 IMAGE:40031440), complete cds.
BC074986 - Homo sapiens F-box protein 16, mRNA (cDNA clone MGC:103914 IMAGE:30915303), complete cds.
KJ900319 - Synthetic construct Homo sapiens clone ccsbBroadEn_09713 FBXO16 gene, encodes complete protein.
JD444358 - Sequence 425382 from Patent EP1572962.
JD309841 - Sequence 290865 from Patent EP1572962.
JD498165 - Sequence 479189 from Patent EP1572962.
JD180498 - Sequence 161522 from Patent EP1572962.
JD243569 - Sequence 224593 from Patent EP1572962.
JD336677 - Sequence 317701 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000380254.1, ENST00000380254.2, ENST00000380254.3, ENST00000380254.4, ENST00000380254.5, ENST00000380254.6, FBX16, FBX16_HUMAN, NM_172366, Q3T1B2, Q3T1B3, Q3T1B4, Q8IX29, uc318pmb.1, uc318pmb.2
UCSC ID: ENST00000380254.7_10
RefSeq Accession: NM_172366.4
Protein: Q8IX29 (aka FBX16_HUMAN or FX16_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.