Human Gene FABP2 (ENST00000274024.4_7) from GENCODE V47lift37
  Description: fatty acid binding protein 2 (from RefSeq NM_000134.4)
Gencode Transcript: ENST00000274024.4_7
Gencode Gene: ENSG00000145384.4_9
Transcript (Including UTRs)
   Position: hg19 chr4:120,238,405-120,243,293 Size: 4,889 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr4:120,240,196-120,243,257 Size: 3,062 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:120,238,405-120,243,293)mRNA (may differ from genome)Protein (132 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FABPI_HUMAN
DESCRIPTION: RecName: Full=Fatty acid-binding protein, intestinal; AltName: Full=Fatty acid-binding protein 2; AltName: Full=Intestinal-type fatty acid-binding protein; Short=I-FABP;
FUNCTION: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.
INDUCTION: By EGF.
DOMAIN: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FABP2
Diseases sorted by gene-association score: perinatal necrotizing enterocolitis (23), refractory celiac disease (18), acute vascular insufficiency of intestine (16), ileitis (8), morbid obesity (8), wheat allergy (6), intestinal atresia (6), hypertrichotic osteochondrodysplasia cantu type (5), diabetes mellitus, noninsulin-dependent (3), obesity (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.15 RPKM in Small Intestine - Terminal Ileum
Total median expression: 78.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.7036-0.186 Picture PostScript Text
3' UTR -409.501791-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012674 - Calycin
IPR011038 - Calycin-like
IPR000463 - Fatty_acid-bd
IPR000566 - Lipocln_cytosolic_FA-bd_dom

Pfam Domains:
PF00061 - Lipocalin / cytosolic fatty-acid binding protein family
PF14651 - Lipocalin / cytosolic fatty-acid binding protein family

SCOP Domains:
50814 - Lipocalins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1KZW - NMR MuPIT 1KZX - NMR MuPIT 3AKM - X-ray MuPIT 3IFB - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P12104
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0036041 long-chain fatty acid binding

Biological Process:
GO:0019433 triglyceride catabolic process
GO:0098856 intestinal lipid absorption

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  KJ896795 - Synthetic construct Homo sapiens clone ccsbBroadEn_06189 FABP2 gene, encodes complete protein.
KR711357 - Synthetic construct Homo sapiens clone CCSBHm_00023116 FABP2 (FABP2) mRNA, encodes complete protein.
AK025079 - Homo sapiens cDNA: FLJ21426 fis, clone COL04163.
JD109107 - Sequence 90131 from Patent EP1572962.
BC069617 - Homo sapiens fatty acid binding protein 2, intestinal, mRNA (cDNA clone MGC:97180 IMAGE:7262424), complete cds.
BC069466 - Homo sapiens fatty acid binding protein 2, intestinal, mRNA (cDNA clone MGC:97202 IMAGE:7262448), complete cds.
BC069637 - Homo sapiens fatty acid binding protein 2, intestinal, mRNA (cDNA clone MGC:97213 IMAGE:7262460), complete cds.
BC069625 - Homo sapiens fatty acid binding protein 2, intestinal, mRNA (cDNA clone MGC:97191 IMAGE:7262436), complete cds.
JD338459 - Sequence 319483 from Patent EP1572962.
JD240605 - Sequence 221629 from Patent EP1572962.
BC111791 - Homo sapiens fatty acid binding protein 2, intestinal, mRNA (cDNA clone MGC:133132 IMAGE:40017872), complete cds.
JD109918 - Sequence 90942 from Patent EP1572962.
JD106126 - Sequence 87150 from Patent EP1572962.
JD069035 - Sequence 50059 from Patent EP1572962.
JD270535 - Sequence 251559 from Patent EP1572962.
JD064523 - Sequence 45547 from Patent EP1572962.
JD299484 - Sequence 280508 from Patent EP1572962.
JD225250 - Sequence 206274 from Patent EP1572962.
JD201139 - Sequence 182163 from Patent EP1572962.
JD342616 - Sequence 323640 from Patent EP1572962.
JD086887 - Sequence 67911 from Patent EP1572962.
JD363256 - Sequence 344280 from Patent EP1572962.
JD324635 - Sequence 305659 from Patent EP1572962.
JD174081 - Sequence 155105 from Patent EP1572962.
JD400467 - Sequence 381491 from Patent EP1572962.
JD249475 - Sequence 230499 from Patent EP1572962.
JD160202 - Sequence 141226 from Patent EP1572962.
JD539533 - Sequence 520557 from Patent EP1572962.
JD166679 - Sequence 147703 from Patent EP1572962.
JD154408 - Sequence 135432 from Patent EP1572962.
JD326201 - Sequence 307225 from Patent EP1572962.
JD040629 - Sequence 21653 from Patent EP1572962.
JD155352 - Sequence 136376 from Patent EP1572962.
CU686944 - Synthetic construct Homo sapiens gateway clone IMAGE:100022536 5' read FABP2 mRNA.
HQ448385 - Synthetic construct Homo sapiens clone IMAGE:100071812; CCSB013983_01 fatty acid binding protein 2, intestinal (FABP2) gene, encodes complete protein.
MG948943 - Homo sapiens fatty acid-binding protein 2 (FABP2), partial sequence; alternatively spliced.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P12104 (Reactome details) participates in the following event(s):

R-HSA-5334794 FABPs bind LCFAs
R-HSA-163560 Triglyceride catabolism
R-HSA-8979227 Triglyceride metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000274024.1, ENST00000274024.2, ENST00000274024.3, FABPI, FABPI_HUMAN, NM_000134, P12104, Q2NKJ1, uc317jdp.1, uc317jdp.2
UCSC ID: ENST00000274024.4_7
RefSeq Accession: NM_000134.4
Protein: P12104 (aka FABPI_HUMAN or FABI_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.