Human Gene EXOC8 (ENST00000366645.1_6) from GENCODE V47lift37
  Description: exocyst complex component 8 (from RefSeq NM_175876.5)
Gencode Transcript: ENST00000366645.1_6
Gencode Gene: ENSG00000116903.7_8
Transcript (Including UTRs)
   Position: hg19 chr1:231,468,499-231,473,598 Size: 5,100 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr1:231,471,314-231,473,491 Size: 2,178 Coding Exon Count: 1 

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Gene AllelesRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:231,468,499-231,473,598)mRNA (may differ from genome)Protein (725 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EXOC8_HUMAN
DESCRIPTION: RecName: Full=Exocyst complex component 8; AltName: Full=Exocyst complex 84 kDa subunit;
FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with the GTP-bound forms of RALA and RALB via its PH domain.
INTERACTION: Q14457:BECN1; NbExp=4; IntAct=EBI-742102, EBI-949378; Q8N6Y0:USHBP1; NbExp=2; IntAct=EBI-742102, EBI-739895;
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, growth cone (By similarity). Note=Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups.
SIMILARITY: Belongs to the EXO84 family.
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=CAI23095.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EXOC8
Diseases sorted by gene-association score: bardet-biedl syndrome 18 (9), babesiosis (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.10107-0.347 Picture PostScript Text
3' UTR -659.802815-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016159 - Cullin_repeat-like_dom
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR014812 - Vps51

Pfam Domains:
PF08700 - Vps51/Vps67
PF16528 - Exocyst component 84 C-terminal

SCOP Domains:
74788 - Cullin repeat-like
140560 - TM0693-like
47661 - t-snare proteins
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q8IYI6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0017160 Ral GTPase binding

Biological Process:
GO:0001927 exocyst assembly
GO:0006887 exocytosis
GO:0007032 endosome organization
GO:0015031 protein transport
GO:0016241 regulation of macroautophagy
GO:0022617 extracellular matrix disassembly
GO:0034613 cellular protein localization
GO:0051601 exocyst localization

Cellular Component:
GO:0000145 exocyst
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030426 growth cone
GO:0031252 cell leading edge
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC035763 - Homo sapiens exocyst complex component 8, mRNA (cDNA clone MGC:46661 IMAGE:5552837), complete cds.
AK096460 - Homo sapiens cDNA FLJ39141 fis, clone NTONG2009576, highly similar to Exocyst complex component 8.
KJ900823 - Synthetic construct Homo sapiens clone ccsbBroadEn_10217 EXOC8 gene, encodes complete protein.
AB587600 - Synthetic construct DNA, clone: pF1KB9886, Homo sapiens EXOC8 gene for exocyst complex component 8, without stop codon, in Flexi system.
CU690194 - Synthetic construct Homo sapiens gateway clone IMAGE:100017783 5' read EXOC8 mRNA.
JD312666 - Sequence 293690 from Patent EP1572962.
JD382143 - Sequence 363167 from Patent EP1572962.
JD170828 - Sequence 151852 from Patent EP1572962.
JD338448 - Sequence 319472 from Patent EP1572962.
JD282510 - Sequence 263534 from Patent EP1572962.
JD267952 - Sequence 248976 from Patent EP1572962.
JD268268 - Sequence 249292 from Patent EP1572962.
JD046989 - Sequence 28013 from Patent EP1572962.
JD279862 - Sequence 260886 from Patent EP1572962.
JD036400 - Sequence 17424 from Patent EP1572962.
JD288104 - Sequence 269128 from Patent EP1572962.
JD294531 - Sequence 275555 from Patent EP1572962.
JD263456 - Sequence 244480 from Patent EP1572962.
JD486196 - Sequence 467220 from Patent EP1572962.
JD314457 - Sequence 295481 from Patent EP1572962.
JD244284 - Sequence 225308 from Patent EP1572962.
JD168976 - Sequence 150000 from Patent EP1572962.
JD068540 - Sequence 49564 from Patent EP1572962.
JD252817 - Sequence 233841 from Patent EP1572962.
JD408393 - Sequence 389417 from Patent EP1572962.
JD395655 - Sequence 376679 from Patent EP1572962.
JD174019 - Sequence 155043 from Patent EP1572962.
JD522209 - Sequence 503233 from Patent EP1572962.
JD526098 - Sequence 507122 from Patent EP1572962.
JD228558 - Sequence 209582 from Patent EP1572962.
JD318287 - Sequence 299311 from Patent EP1572962.
JD396568 - Sequence 377592 from Patent EP1572962.
JD126150 - Sequence 107174 from Patent EP1572962.
JD390188 - Sequence 371212 from Patent EP1572962.
JD054804 - Sequence 35828 from Patent EP1572962.
JD365721 - Sequence 346745 from Patent EP1572962.
JD528872 - Sequence 509896 from Patent EP1572962.
DQ572553 - Homo sapiens piRNA piR-40665, complete sequence.
JD197191 - Sequence 178215 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IYI6 (Reactome details) participates in the following event(s):

R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex
R-HSA-264876 Insulin processing
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-2980736 Peptide hormone metabolism
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: B3KU33, EXOC8_HUMAN, NM_175876, Q5TE82, Q8IYI6, uc318fgk.1, uc318fgk.2
UCSC ID: ENST00000366645.1_6
RefSeq Accession: NM_175876.5
Protein: Q8IYI6 (aka EXOC8_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.