ID:ERAP2_HUMAN DESCRIPTION: RecName: Full=Endoplasmic reticulum aminopeptidase 2; EC=3.4.11.-; AltName: Full=Leukocyte-derived arginine aminopeptidase; Short=L-RAP; FUNCTION: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Heterodimer with ERAP1. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Ubiquitously expressed. Highly expressed in spleen and leukocytes. INDUCTION: By IFNG/IFN-gamma. PTM: N-glycosylated. MISCELLANEOUS: Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance. SIMILARITY: Belongs to the peptidase M1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P179
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002250 adaptive immune response GO:0002376 immune system process GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0006508 proteolysis GO:0007165 signal transduction GO:0007267 cell-cell signaling GO:0008217 regulation of blood pressure GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0043171 peptide catabolic process
AK074281 - Homo sapiens cDNA FLJ23701 fis, clone HEP10760, highly similar to Homo sapiens aminopeptidase mRNA. AK312864 - Homo sapiens cDNA, FLJ93308, highly similar to Homo sapiens leukocyte-derived arginine aminopeptidase (LRAP), mRNA. AB109031 - Homo sapiens l-rap mRNA for leukocyte-derived arginine aminopeptidase long form variant, complete cds. AB163917 - Homo sapiens l-rap mRNA for leukocyte-derived arginine aminopeptidase short form variant 2, complete cds. BC065240 - Homo sapiens endoplasmic reticulum aminopeptidase 2, mRNA (cDNA clone MGC:74931 IMAGE:6166289), complete cds. BC017927 - Homo sapiens endoplasmic reticulum aminopeptidase 2, mRNA (cDNA clone IMAGE:4337700), complete cds. AF191545 - Homo sapiens aminopeptidase mRNA, complete cds. AY028805 - Homo sapiens leukocyte-derived arginine aminopeptidase short form mRNA, complete cds, alternatively spliced. JD411732 - Sequence 392756 from Patent EP1572962. AB385154 - Synthetic construct DNA, clone: pF1KB5679, Homo sapiens ERAP2 gene for leukocyte-derived arginine aminopeptidase, complete cds, without stop codon, in Flexi system. AK074387 - Homo sapiens cDNA FLJ23807 fis, clone HRC03762, highly similar to Homo sapiens aminopeptidase mRNA. JD022941 - Sequence 3965 from Patent EP1572962. JD029517 - Sequence 10541 from Patent EP1572962. AK074213 - Homo sapiens cDNA FLJ23633 fis, clone CAS05313, highly similar to Homo sapiens aminopeptidase mRNA. JD313585 - Sequence 294609 from Patent EP1572962. JD433684 - Sequence 414708 from Patent EP1572962. JD432469 - Sequence 413493 from Patent EP1572962. JD056832 - Sequence 37856 from Patent EP1572962. JD088410 - Sequence 69434 from Patent EP1572962. JD320275 - Sequence 301299 from Patent EP1572962. JD410446 - Sequence 391470 from Patent EP1572962. JD136165 - Sequence 117189 from Patent EP1572962. JD079533 - Sequence 60557 from Patent EP1572962. JD405288 - Sequence 386312 from Patent EP1572962. JD156659 - Sequence 137683 from Patent EP1572962. JD113377 - Sequence 94401 from Patent EP1572962. JD149476 - Sequence 130500 from Patent EP1572962. JD518046 - Sequence 499070 from Patent EP1572962. JD518048 - Sequence 499072 from Patent EP1572962. JD117309 - Sequence 98333 from Patent EP1572962. JD106067 - Sequence 87091 from Patent EP1572962. JD220083 - Sequence 201107 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6P179 (Reactome details) participates in the following event(s):
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
