ID:IF4A2_HUMAN DESCRIPTION: RecName: Full=Eukaryotic initiation factor 4A-II; Short=eIF-4A-II; Short=eIF4A-II; EC=3.6.4.13; AltName: Full=ATP-dependent RNA helicase eIF4A-2; FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs. INTERACTION: Q04637:EIF4G1; NbExp=3; IntAct=EBI-73473, EBI-73711; SIMILARITY: Belongs to the DEAD box helicase family. eIF4A subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EIF4A2ID262.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14240
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006412 translation GO:0006413 translational initiation GO:0006446 regulation of translational initiation GO:0010501 RNA secondary structure unwinding GO:0016032 viral process GO:1900260 negative regulation of RNA-directed 5'-3' RNA polymerase activity
Cellular Component: GO:0005730 nucleolus GO:0005829 cytosol GO:0016281 eukaryotic translation initiation factor 4F complex GO:0048471 perinuclear region of cytoplasm
Descriptions from all associated GenBank mRNAs
AK225646 - Homo sapiens mRNA for Eukaryotic initiation factor 4A-II variant, clone: STM00487. BC048105 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 2, mRNA (cDNA clone MGC:57298 IMAGE:4820774), complete cds. BC012547 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 2, mRNA (cDNA clone MGC:13368 IMAGE:4079371), complete cds. BC015842 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 2, mRNA (cDNA clone MGC:27241 IMAGE:4337581), complete cds. AK130087 - Homo sapiens cDNA FLJ26577 fis, clone LNF06701, highly similar to Eukaryotic initiation factor 4A-II. AL117412 - Homo sapiens mRNA; cDNA DKFZp566L241 (from clone DKFZp566L241). BC013708 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 2, mRNA (cDNA clone MGC:21863 IMAGE:4341420), complete cds. D30655 - Homo sapiens mRNA for eukaryotic initiation factor 4AII, complete cds. BC006469 - Homo sapiens cDNA clone IMAGE:2821004, containing frame-shift errors. S79942 - EIF4A2=protein synthesis initiation factor 4A-II homolog [human, fetal lung tissue, mRNA Partial, 1881 nt]. AF208852 - Homo sapiens BM-010 mRNA, complete cds. CU677469 - Synthetic construct Homo sapiens gateway clone IMAGE:100017642 5' read EIF4A2 mRNA. CU680354 - Synthetic construct Homo sapiens gateway clone IMAGE:100018236 5' read EIF4A2 mRNA. CU690550 - Synthetic construct Homo sapiens gateway clone IMAGE:100020931 5' read EIF4A2 mRNA. AB590233 - Synthetic construct DNA, clone: pFN21AE1545, Homo sapiens EIF4A2 gene for eukaryotic translation initiation factor 4A, isoform 2, without stop codon, in Flexi system. DQ894914 - Synthetic construct Homo sapiens clone IMAGE:100009374; FLH179537.01L; RZPDo839H08129D eukaryotic translation initiation factor 4A, isoform 2 (EIF4A2) gene, encodes complete protein. KJ905737 - Synthetic construct Homo sapiens clone ccsbBroadEn_15407 EIF4A2 gene, encodes complete protein. DQ891738 - Synthetic construct clone IMAGE:100004368; FLH179541.01X; RZPDo839H08130D eukaryotic translation initiation factor 4A, isoform 2 (EIF4A2) gene, encodes complete protein. KJ896754 - Synthetic construct Homo sapiens clone ccsbBroadEn_06148 EIF4A2 gene, encodes complete protein. KJ904456 - Synthetic construct Homo sapiens clone ccsbBroadEn_13850 EIF4A2 gene, encodes complete protein. KJ904457 - Synthetic construct Homo sapiens clone ccsbBroadEn_13851 EIF4A2 gene, encodes complete protein. BT009860 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 2 mRNA, complete cds. AB209021 - Homo sapiens mRNA for BM-010 variant protein. AY207392 - Homo sapiens eukaryotic translation initiation factor 4A isoform 2-like protein mRNA, partial cds. AL137681 - Homo sapiens mRNA; cDNA DKFZp434M0326 (from clone DKFZp434M0326). AK296279 - Homo sapiens cDNA FLJ58834 complete cds, highly similar to Eukaryotic initiation factor 4A-II (EC 3.6.1.-). BC016295 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 2, mRNA (cDNA clone IMAGE:3912165), complete cds. JD269011 - Sequence 250035 from Patent EP1572962. AF086153 - Homo sapiens full length insert cDNA clone ZB55E11. AF268384 - Homo sapiens clone DPDP-1 dental pulp-derived protein 1, mRNA sequence. JD025945 - Sequence 6969 from Patent EP1572962. JD032689 - Sequence 13713 from Patent EP1572962. JD165971 - Sequence 146995 from Patent EP1572962. JD147973 - Sequence 128997 from Patent EP1572962. JD506877 - Sequence 487901 from Patent EP1572962. JD299459 - Sequence 280483 from Patent EP1572962. JD563345 - Sequence 544369 from Patent EP1572962. JD528331 - Sequence 509355 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_mTORPathway - mTOR Signaling Pathway h_iresPathway - Internal Ribosome entry pathway h_eifPathway - Eukaryotic protein translation h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
Reactome (by CSHL, EBI, and GO)
Protein Q14240 (Reactome details) participates in the following event(s):
R-HSA-72631 Formation of the cap-binding eIF4F complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-429955 CCR4-NOT complex deadenylates mRNA R-HSA-429992 PARN deadenylates mRNA R-HSA-72635 eIF4F binds to mRNP R-HSA-430021 PAN2-PAN3 complex partially deadenylates mRNA R-HSA-8941312 ZCCHC6, ZCCHC11 are mRNA uridyltransferases R-HSA-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP R-HSA-72621 Ribosomal scanning R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-429947 Deadenylation of mRNA R-HSA-72737 Cap-dependent Translation Initiation R-HSA-1169408 ISG15 antiviral mechanism R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72649 Translation initiation complex formation R-HSA-156827 L13a-mediated translation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-8953854 Metabolism of RNA R-HSA-72766 Translation R-HSA-913531 Interferon Signaling R-HSA-392499 Metabolism of proteins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
