ID:IF4A1_HUMAN DESCRIPTION: RecName: Full=Eukaryotic initiation factor 4A-I; Short=eIF-4A-I; Short=eIF4A-I; EC=3.6.4.13; AltName: Full=ATP-dependent RNA helicase eIF4A-1; FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. ENZYME REGULATION: Helicase activity and function in translation are inhibited by interaction with PDCD4. SUBUNIT: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69. INTERACTION: Q04637:EIF4G1; NbExp=7; IntAct=EBI-73449, EBI-73711; P78344:EIF4G2; NbExp=2; IntAct=EBI-73449, EBI-296519; Q15056:EIF4H; NbExp=2; IntAct=EBI-73449, EBI-748492; SIMILARITY: Belongs to the DEAD box helicase family. eIF4A subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P60842
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC032613 - Homo sapiens cDNA clone IMAGE:5555330, **** WARNING: chimeric clone ****. AK303599 - Homo sapiens cDNA FLJ57766 complete cds, moderately similar to Eukaryotic initiation factor 4A-I (EC 3.6.1.-). AK296664 - Homo sapiens cDNA FLJ58012 complete cds, moderately similar to Eukaryotic initiation factor 4A-I (EC 3.6.1.-). AK312630 - Homo sapiens cDNA, FLJ93014, Homo sapiens eukaryotic translation initiation factor 4A, isoform 1(EIF4A1), mRNA. AK130082 - Homo sapiens cDNA FLJ26572 fis, clone LNF05779, highly similar to Eukaryotic initiation factor 4A-I (eIF-4A-I). D13748 - Homo sapiens mRNA for eukaryotic initiation factor 4AI, complete cds. AK291971 - Homo sapiens cDNA FLJ78244 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 4A, isoform 1 (EIF4A1), mRNA. AK303222 - Homo sapiens cDNA FLJ59127 complete cds, highly similar to Eukaryotic initiation factor 4A-I (EC 3.6.1.-). AK309274 - Homo sapiens cDNA, FLJ99315. BC009585 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 1, mRNA (cDNA clone MGC:14648 IMAGE:4096621), complete cds. AK297916 - Homo sapiens cDNA FLJ58596 complete cds, highly similar to Eukaryotic initiation factor 4A-I (EC 3.6.1.-). AK289453 - Homo sapiens cDNA FLJ78614 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 4A, isoform 1 (EIF4A1), mRNA. BC006210 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 1, mRNA (cDNA clone IMAGE:2821876), partial cds. BC073752 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 1, mRNA (cDNA clone MGC:88756 IMAGE:6371531), complete cds. CU679411 - Synthetic construct Homo sapiens gateway clone IMAGE:100019261 5' read EIF4A1 mRNA. DQ893044 - Synthetic construct clone IMAGE:100005674; FLH192962.01X; RZPDo839B0378D eukaryotic translation initiation factor 4A, isoform 1 (EIF4A1) gene, encodes complete protein. AB385527 - Synthetic construct DNA, clone: pF1KB3435, Homo sapiens EIF4A1 gene for eukaryotic initiation factor 4A-I, complete cds, without stop codon, in Flexi system. DQ896288 - Synthetic construct Homo sapiens clone IMAGE:100010748; FLH192958.01L; RZPDo839B0368D eukaryotic translation initiation factor 4A, isoform 1 (EIF4A1) gene, encodes complete protein. KJ896753 - Synthetic construct Homo sapiens clone ccsbBroadEn_06147 EIF4A1 gene, encodes complete protein. BT019880 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 1 mRNA, complete cds. BT019881 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 1 mRNA, complete cds. BC032078 - Homo sapiens eukaryotic translation initiation factor 4A, isoform 1, mRNA (cDNA clone IMAGE:3880019). AB209593 - Homo sapiens mRNA for CD68 antigen variant protein. JD023858 - Sequence 4882 from Patent EP1572962. JD030887 - Sequence 11911 from Patent EP1572962. U79273 - Human clone 23933 mRNA sequence. BC006380 - Homo sapiens cDNA clone IMAGE:4099962, **** WARNING: chimeric clone ****. DQ598738 - Homo sapiens piRNA piR-36804, complete sequence. DQ585397 - Homo sapiens piRNA piR-52509, complete sequence. JD025796 - Sequence 6820 from Patent EP1572962. JD199139 - Sequence 180163 from Patent EP1572962. CQ873845 - Sequence 264 from Patent WO2004076622. DD413682 - Regulation of Mammalian Cells. JD126665 - Sequence 107689 from Patent EP1572962. JD126666 - Sequence 107690 from Patent EP1572962. JD189387 - Sequence 170411 from Patent EP1572962. JD384240 - Sequence 365264 from Patent EP1572962. JD426356 - Sequence 407380 from Patent EP1572962. JD498653 - Sequence 479677 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_iresPathway - Internal Ribosome entry pathway h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase h_mTORPathway - mTOR Signaling Pathway h_eifPathway - Eukaryotic protein translation
Reactome (by CSHL, EBI, and GO)
Protein P60842 (Reactome details) participates in the following event(s):
R-HSA-72631 Formation of the cap-binding eIF4F complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-429955 CCR4-NOT complex deadenylates mRNA R-HSA-429992 PARN deadenylates mRNA R-HSA-72635 eIF4F binds to mRNP R-HSA-430021 PAN2-PAN3 complex partially deadenylates mRNA R-HSA-8941312 ZCCHC6, ZCCHC11 are mRNA uridyltransferases R-HSA-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP R-HSA-72621 Ribosomal scanning R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-429947 Deadenylation of mRNA R-HSA-72737 Cap-dependent Translation Initiation R-HSA-1169408 ISG15 antiviral mechanism R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72649 Translation initiation complex formation R-HSA-156827 L13a-mediated translation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-8953854 Metabolism of RNA R-HSA-72766 Translation R-HSA-913531 Interferon Signaling R-HSA-392499 Metabolism of proteins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
