Human Gene EIF3H (ENST00000521861.6_12) from GENCODE V47lift37

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Description: eukaryotic translation initiation factor 3 subunit H (from RefSeq NM_003756.3)
Gencode Transcript: ENST00000521861.6_12
Gencode Gene: ENSG00000147677.12_15
Transcript (Including UTRs)
Position: hg19 chr8:117,654,369-117,768,062 Size: 113,694 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr8:117,657,245-117,768,036 Size: 110,792 Coding Exon Count: 8

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:117,654,369-117,768,062)			mRNA (may differ from genome)		Protein (352 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: EIF3H Diseases sorted by gene-association score: trichorhinophalangeal syndrome, type i (8), trichorhinophalangeal syndrome, type ii (7), prostate cancer (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D013749 Tetrachlorodibenzodioxin C009505 4,4'-diaminodiphenylmethane D019256 Cadmium Chloride D002995 Clofibric Acid D003993 Dibutyl Phthalate D004052 Diethylnitrosamine D004997 Ethinyl Estradiol D005472 Fluorouracil D005839 Gentamicins more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 87.69 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 1608.56 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-2.80	26	-0.108	Picture	PostScript	Text
3' UTR	-729.01	2876	-0.253	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000555 - JAB1_Mov34_MPN_PAD1

Pfam Domains:
PF01398 - JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PF19445 - C-terminal region of eIF3h

ModBase Predicted Comparative 3D Structure on Q6IB98


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details			Gene Details
Gene Sorter			Gene Sorter
		Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003743 translation initiation factor activity GO:0005515 protein binding Biological Process: GO:0001732 formation of cytoplasmic translation initiation complex GO:0002183 cytoplasmic translational initiation GO:0006412 translation GO:0006413 translational initiation Cellular Component: GO:0005737 cytoplasm GO:0005852 eukaryotic translation initiation factor 3 complex GO:0016282 eukaryotic 43S preinitiation complex GO:0033290 eukaryotic 48S preinitiation complex GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m

Descriptions from all associated GenBank mRNAs


	BC000386 - Homo sapiens eukaryotic translation initiation factor 3, subunit H, mRNA (cDNA clone MGC:8431 IMAGE:2821133), complete cds. BC090880 - Homo sapiens eukaryotic translation initiation factor 3, subunit H, mRNA (cDNA clone MGC:102958 IMAGE:30367209), complete cds. AK222520 - Homo sapiens mRNA for eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa variant, clone: adSE01270. AK093128 - Homo sapiens cDNA FLJ35809 fis, clone TESTI2006016, highly similar to Eukaryotic translation initiation factor 3 subunit 3. U54559 - Homo sapiens translation initiation factor eIF3 p40 subunit mRNA, complete cds. AK222620 - Homo sapiens mRNA for eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa variant, clone: CBL00213. CR456906 - Homo sapiens full open reading frame cDNA clone RZPDo834F0211D for gene EIF3S3, eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; complete cds, incl. stopcodon. BT019594 - Homo sapiens eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa mRNA, complete cds. KJ892591 - Synthetic construct Homo sapiens clone ccsbBroadEn_01985 EIF3H gene, encodes complete protein. CU674186 - Synthetic construct Homo sapiens gateway clone IMAGE:100018172 5' read EIF3H mRNA. AK296162 - Homo sapiens cDNA FLJ57508 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 3. JD081597 - Sequence 62621 from Patent EP1572962. JD414818 - Sequence 395842 from Patent EP1572962. DQ574995 - Homo sapiens piRNA piR-43107, complete sequence. JD525282 - Sequence 506306 from Patent EP1572962. JD311800 - Sequence 292824 from Patent EP1572962. JD094119 - Sequence 75143 from Patent EP1572962. JD294963 - Sequence 275987 from Patent EP1572962. JD120564 - Sequence 101588 from Patent EP1572962. JD379674 - Sequence 360698 from Patent EP1572962. JD120563 - Sequence 101587 from Patent EP1572962. JD414817 - Sequence 395841 from Patent EP1572962. JD352599 - Sequence 333623 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: EIF3H , EIF3S3 , ENST00000521861.1, ENST00000521861.2, ENST00000521861.3, ENST00000521861.4, ENST00000521861.5, hCG_20900 , NM_003756, Q6IB98, Q6IB98_HUMAN, uc323vqq.1, uc323vqq.2 UCSC ID: ENST00000521861.6_12 RefSeq Accession: NM_003756.3 Protein: Q6IB98

Gene Model Information


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Methods, Credits, and Use Restrictions


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