Human Gene DUSP7 (ENST00000495880.2_7) from GENCODE V47lift37
  Description: dual specificity phosphatase 7 (from RefSeq NM_001947.4)
Gencode Transcript: ENST00000495880.2_7
Gencode Gene: ENSG00000164086.10_12
Transcript (Including UTRs)
   Position: hg19 chr3:52,082,935-52,090,587 Size: 7,653 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr3:52,084,831-52,090,382 Size: 5,552 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:52,082,935-52,090,587)mRNA (may differ from genome)Protein (419 aa)
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-  Comments and Description Text from UniProtKB
  ID: DUS7_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 7; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity protein phosphatase PYST2;
FUNCTION: Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
INTERACTION: P10912:GHR; NbExp=2; IntAct=EBI-1265847, EBI-286316;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 rhodanese domain.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CAUTION: An out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the alternative promoter. The expression of the in-frame product has not yet been shown.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.51 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 366.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.10205-0.683 Picture PostScript Text
3' UTR -672.801896-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR008343 - MKP
IPR001763 - Rhodanese-like_dom
IPR000387 - Tyr/Dual-specificity_Pase

Pfam Domains:
PF00581 - Rhodanese-like domain
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II
52821 - Rhodanese/Cell cycle control phosphatase

ModBase Predicted Comparative 3D Structure on Q16829
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0043407 negative regulation of MAP kinase activity

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  KJ901395 - Synthetic construct Homo sapiens clone ccsbBroadEn_10789 DUSP7 gene, encodes complete protein.
MN277353 - Homo sapiens IGL c913_light_IGKV3-15_IGKJ1 mRNA, partial cds.
AL110157 - Homo sapiens mRNA; cDNA DKFZp586F2224 (from clone DKFZp586F2224).
X93921 - H.sapiens mRNA for protein-tyrosine-phosphatase (tissue type: testis).
JD549605 - Sequence 530629 from Patent EP1572962.
BC019107 - Homo sapiens dual specificity phosphatase 7, mRNA (cDNA clone IMAGE:5095103), partial cds.
JD173017 - Sequence 154041 from Patent EP1572962.
JD203404 - Sequence 184428 from Patent EP1572962.
JD173484 - Sequence 154508 from Patent EP1572962.
JD203600 - Sequence 184624 from Patent EP1572962.
JD161206 - Sequence 142230 from Patent EP1572962.
JD128487 - Sequence 109511 from Patent EP1572962.
JD191860 - Sequence 172884 from Patent EP1572962.
JD210582 - Sequence 191606 from Patent EP1572962.
JD387066 - Sequence 368090 from Patent EP1572962.
JD162372 - Sequence 143396 from Patent EP1572962.
JD193675 - Sequence 174699 from Patent EP1572962.
JD335097 - Sequence 316121 from Patent EP1572962.
BC104880 - Homo sapiens dual specificity phosphatase 7, mRNA (cDNA clone MGC:132540 IMAGE:8143883), complete cds.
BC104882 - Homo sapiens dual specificity phosphatase 7, mRNA (cDNA clone MGC:132542 IMAGE:8143885), complete cds.
JD107157 - Sequence 88181 from Patent EP1572962.
JD101418 - Sequence 82442 from Patent EP1572962.
AF508728 - Homo sapiens PYST2-S (PYST2) mRNA sequence, alternatively spliced.
AF508727 - Homo sapiens dual-specificity phosphatase 7 PYST2-L (PYST2) mRNA, complete cds, alternatively spliced.
JD057682 - Sequence 38706 from Patent EP1572962.
JD216835 - Sequence 197859 from Patent EP1572962.
JD125855 - Sequence 106879 from Patent EP1572962.
JD157410 - Sequence 138434 from Patent EP1572962.
JD472019 - Sequence 453043 from Patent EP1572962.
JD141707 - Sequence 122731 from Patent EP1572962.
JD408553 - Sequence 389577 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q16829 (Reactome details) participates in the following event(s):

R-HSA-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs)
R-HSA-5675376 Cytosolic DUSPs dephosphorylate MAPKs
R-HSA-202670 ERKs are inactivated
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-198753 ERK/MAPK targets
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-5683057 MAPK family signaling cascades
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-450294 MAP kinase activation
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-449147 Signaling by Interleukins
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168249 Innate Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: DUS7_HUMAN, DUSP7 , ENST00000495880.1, NM_001947, PYST2 , Q16829, Q2M3J7, Q8NFJ0, uc322rpy.1, uc322rpy.2
UCSC ID: ENST00000495880.2_7
RefSeq Accession: NM_001947.4
Protein: Q16829 (aka DUS7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.