Human Gene DUSP5 (ENST00000369583.4_4) from GENCODE V47lift37

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Description: dual specificity phosphatase 5 (from RefSeq NM_004419.4)
Gencode Transcript: ENST00000369583.4_4
Gencode Gene: ENSG00000138166.6_7
Transcript (Including UTRs)
Position: hg19 chr10:112,257,665-112,271,291 Size: 13,627 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr10:112,257,880-112,270,184 Size: 12,305 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:112,257,665-112,271,291)			mRNA (may differ from genome)		Protein (384 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DUS5_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 5; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity protein phosphatase hVH3; FUNCTION: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 rhodanese domain. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DUSP5 Diseases sorted by gene-association score: lymphoma, malt, somatic (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D003993 Dibutyl Phthalate D004997 Ethinyl Estradiol D013749 Tetrachlorodibenzodioxin D015032 Zinc C006780 bisphenol A C006253 pirinixic acid C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C016403 2,4-dinitrotoluene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 54.33 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 552.76 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-139.90	215	-0.651	Picture	PostScript	Text
3' UTR	-325.90	1107	-0.294	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR008343 - MKP
IPR001763 - Rhodanese-like_dom
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase
PF00581 - Rhodanese-like domain
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II
52821 - Rhodanese/Cell cycle control phosphatase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2G6Z - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q16690


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0005515 protein binding GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0016787 hydrolase activity GO:0016791 phosphatase activity GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity Biological Process: GO:0000165 MAPK cascade GO:0000187 activation of MAPK activity GO:0000188 inactivation of MAPK activity GO:0001706 endoderm formation GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035970 peptidyl-threonine dephosphorylation Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm

Descriptions from all associated GenBank mRNAs


	AB209823 - Homo sapiens mRNA for dual specificity phosphatase 5 variant protein. U15932 - Human dual-specificity protein phosphatase mRNA, complete cds. BC062545 - Homo sapiens dual specificity phosphatase 5, mRNA (cDNA clone MGC:71194 IMAGE:5808876), complete cds. JD458581 - Sequence 439605 from Patent EP1572962. JD399229 - Sequence 380253 from Patent EP1572962. U16996 - Human protein tyrosine phosphatase mRNA, complete cds. AB489171 - Synthetic construct DNA, clone: pF1KB5402, Homo sapiens DUSP gene for dual specificity phosphatase 5, without stop codon, in Flexi system. EU831449 - Synthetic construct Homo sapiens clone HAIB:100066478; DKFZo008E0117 dual specificity phosphatase 5 protein (DUSP5) gene, encodes complete protein. EU831536 - Synthetic construct Homo sapiens clone HAIB:100066565; DKFZo004E0118 dual specificity phosphatase 5 protein (DUSP5) gene, encodes complete protein. JD250467 - Sequence 231491 from Patent EP1572962. JD319933 - Sequence 300957 from Patent EP1572962. JD530009 - Sequence 511033 from Patent EP1572962. JD109183 - Sequence 90207 from Patent EP1572962. JD185194 - Sequence 166218 from Patent EP1572962. JD465774 - Sequence 446798 from Patent EP1572962. JD300556 - Sequence 281580 from Patent EP1572962. JD056458 - Sequence 37482 from Patent EP1572962. JD221230 - Sequence 202254 from Patent EP1572962. JD155393 - Sequence 136417 from Patent EP1572962. JD042132 - Sequence 23156 from Patent EP1572962. JD327359 - Sequence 308383 from Patent EP1572962. JD545522 - Sequence 526546 from Patent EP1572962. JD286536 - Sequence 267560 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q16690 (Reactome details) participates in the following event(s): R-HSA-5675373 Nuclear DUSPs dephosphorylate MAPKs R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: DUS5_HUMAN, ENST00000369583.1, ENST00000369583.2, ENST00000369583.3, NM_004419, Q12997, Q16690, Q5T603, uc318hrt.1, uc318hrt.2, VH3 UCSC ID: ENST00000369583.4_4 RefSeq Accession: NM_004419.4 Protein: Q16690 (aka DUS5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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