Human Gene DUSP21 (ENST00000339042.6_4) from GENCODE V47lift37
  Description: dual specificity phosphatase 21 (from RefSeq NM_022076.4)
Gencode Transcript: ENST00000339042.6_4
Gencode Gene: ENSG00000189037.8_8
Transcript (Including UTRs)
   Position: hg19 chrX:44,703,267-44,704,134 Size: 868 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chrX:44,703,379-44,703,951 Size: 573 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:44,703,267-44,704,134)mRNA (may differ from genome)Protein (190 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUS21_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 21; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Low molecular weight dual specificity phosphatase 21; Short=LMW-DSP21;
FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
TISSUE SPECIFICITY: Expressed in testis.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.59 RPKM in Testis
Total median expression: 9.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.70112-0.247 Picture PostScript Text
3' UTR -43.40183-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020417 - Atypical_DUSP
IPR020420 - Atypical_DUSP_famB
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II
159659 - Cgl1923-like

ModBase Predicted Comparative 3D Structure on Q9H596
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process:
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0031314 extrinsic component of mitochondrial inner membrane


-  Descriptions from all associated GenBank mRNAs
  AF533018 - Homo sapiens low molecular weight dual specificity phosphatase 21 (LMWDSP21) mRNA, complete cds.
AF143321 - Homo sapiens clone IMAGE:109914 mRNA sequence.
AY121807 - Homo sapiens BJ-HCC-26 tumor antigen mRNA, complete cds.
AY156515 - Homo sapiens DUSP-like protein mRNA, complete cds.
JD545919 - Sequence 526943 from Patent EP1572962.
JD266240 - Sequence 247264 from Patent EP1572962.
BC119755 - Homo sapiens dual specificity phosphatase 21, mRNA (cDNA clone MGC:149877 IMAGE:40119299), complete cds.
BC119756 - Homo sapiens dual specificity phosphatase 21, mRNA (cDNA clone MGC:149878 IMAGE:40119300), complete cds.
KJ894511 - Synthetic construct Homo sapiens clone ccsbBroadEn_03905 DUSP21 gene, encodes complete protein.
CR457159 - Homo sapiens full open reading frame cDNA clone RZPDo834A058D for gene DUSP21, dual specificity phosphatase 21; complete cds, incl. stopcodon.
JD089880 - Sequence 70904 from Patent EP1572962.
JD086072 - Sequence 67096 from Patent EP1572962.
JD264114 - Sequence 245138 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DUS21_HUMAN, ENST00000339042.1, ENST00000339042.2, ENST00000339042.3, ENST00000339042.4, ENST00000339042.5, LMWDSP21, NM_022076, Q0VDA6, Q6IAJ6, Q6YDQ8, Q9H596, uc317vfo.1, uc317vfo.2
UCSC ID: ENST00000339042.6_4
RefSeq Accession: NM_022076.4
Protein: Q9H596 (aka DUS21_HUMAN or DUSL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.