Human Gene DUSP13A (ENST00000372702.7_10) from GENCODE V47lift37
  Description: Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1- mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1. (from UniProt Q6B8I1)
Gencode Transcript: ENST00000372702.7_10
Gencode Gene: ENSG00000293543.1_3
Transcript (Including UTRs)
   Position: hg19 chr10:76,854,192-76,868,979 Size: 14,788 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr10:76,865,427-76,868,915 Size: 3,489 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:76,854,192-76,868,979)mRNA (may differ from genome)Protein (188 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: MDSP_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 13 isoform MDSP; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Branching-enzyme interacting DSP; AltName: Full=Muscle-restricted DSP;
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
ENZYME REGULATION: Inhibited by vanadate.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0);
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Skeletal muscle specific.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.06 RPKM in Muscle - Skeletal
Total median expression: 92.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.2064-0.175 Picture PostScript Text
3' UTR -463.301147-0.404 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020417 - Atypical_DUSP
IPR020405 - Atypical_DUSP_famA
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

ModBase Predicted Comparative 3D Structure on Q6B8I1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB027004 - Homo sapiens mRNA for protein phosphatase, complete cds.
AB103375 - Homo sapiens SKRP4 mRNA for dual-specificity phosphatase SKRP4, complete cds.
AK057012 - Homo sapiens cDNA FLJ32450 fis, clone SKMUS2001663, highly similar to Dual specificity protein phosphatase 13 (EC 3.1.3.48).
AK127886 - Homo sapiens cDNA FLJ45992 fis, clone SKMUS2008585, highly similar to Homo sapiens dual specificity phosphatase 13 (DUSP13), transcript variant 3, mRNA.
BC009778 - Homo sapiens dual specificity phosphatase 13, mRNA (cDNA clone MGC:13471 IMAGE:4047963), complete cds.
AY040091 - Homo sapiens branching-enzyme interacting dual-specificity protein phosphatase BEDP mRNA, complete cds.
AY674051 - Homo sapiens muscle restricted dual specificity phosphatase (DUSP13) mRNA, complete cds.
JD208019 - Sequence 189043 from Patent EP1572962.
JD485081 - Sequence 466105 from Patent EP1572962.
JD544373 - Sequence 525397 from Patent EP1572962.
JD362762 - Sequence 343786 from Patent EP1572962.
JD182920 - Sequence 163944 from Patent EP1572962.
JD123236 - Sequence 104260 from Patent EP1572962.
JD054316 - Sequence 35340 from Patent EP1572962.
AK300679 - Homo sapiens cDNA FLJ61416 complete cds, highly similar to Homo sapiens dual specificity phosphatase 13 (DUSP13), transcript variant 3, mRNA.
AK291897 - Homo sapiens cDNA FLJ77806 complete cds.
JD474692 - Sequence 455716 from Patent EP1572962.
AK291891 - Homo sapiens cDNA FLJ77791 complete cds.
DQ892732 - Synthetic construct clone IMAGE:100005362; FLH189201.01X; RZPDo839C0874D dual specificity phosphatase 13 (DUSP13) gene, encodes complete protein.
DQ895979 - Synthetic construct Homo sapiens clone IMAGE:100010439; FLH189197.01L; RZPDo839C0864D dual specificity phosphatase 13 (DUSP13) gene, encodes complete protein.
KJ898860 - Synthetic construct Homo sapiens clone ccsbBroadEn_08254 DUSP13 gene, encodes complete protein.
AB463584 - Synthetic construct DNA, clone: pF1KB6344, Homo sapiens DUSP13 gene for dual specificity phosphatase 13, without stop codon, in Flexi system.
CR457094 - Homo sapiens full open reading frame cDNA clone RZPDo834F077D for gene DUSP13, dual specificity phosphatase 13; complete cds, incl. stopcodon.
JD080575 - Sequence 61599 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AY674051, BEDP, DS13A_HUMAN, DUSP13, ENST00000372702.1, ENST00000372702.2, ENST00000372702.3, ENST00000372702.4, ENST00000372702.5, ENST00000372702.6, MDSP, Q6B8I1, Q96J67, uc318kdi.1, uc318kdi.2
UCSC ID: ENST00000372702.7_10
Representative RNA: AY674051
Protein: Q6B8I1 (aka MDSP_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.