Human Gene DOK3 (ENST00000510898.7_8) from GENCODE V47lift37
  Description: docking protein 3, transcript variant 1 (from RefSeq NM_024872.4)
Gencode Transcript: ENST00000510898.7_8
Gencode Gene: ENSG00000146094.16_11
Transcript (Including UTRs)
   Position: hg19 chr5:176,928,905-176,936,827 Size: 7,923 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr5:176,930,984-176,936,541 Size: 5,558 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:176,928,905-176,936,827)mRNA (may differ from genome)Protein (440 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: D6RAM3_HUMAN
DESCRIPTION: SubName: Full=Docking protein 3;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 143.85 RPKM in Whole Blood
Total median expression: 357.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.40186-0.405 Picture PostScript Text
3' UTR -685.372079-0.330 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002404 - Insln_rcpt_S1
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF02174 - PTB domain (IRS-1 type)

SCOP Domains:
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on D6RAM3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AL833678 - Homo sapiens mRNA; cDNA DKFZp667C1322 (from clone DKFZp667C1322).
BC004867 - Homo sapiens docking protein 3, mRNA (cDNA clone IMAGE:3678701), complete cds.
BC004564 - Homo sapiens docking protein 3, mRNA (cDNA clone MGC:10476 IMAGE:4054381), complete cds.
AK097258 - Homo sapiens cDNA FLJ39939 fis, clone SPLEN2022227, moderately similar to Mus musculus adaptor protein (Dokl) mRNA.
KJ899595 - Synthetic construct Homo sapiens clone ccsbBroadEn_08989 DOK3 gene, encodes complete protein.
AB528017 - Synthetic construct DNA, clone: pF1KE0755, Homo sapiens DOK3 gene for docking protein 3, without stop codon, in Flexi system.
AK026223 - Homo sapiens cDNA: FLJ22570 fis, clone HSI02155.
JD535085 - Sequence 516109 from Patent EP1572962.
JD203163 - Sequence 184187 from Patent EP1572962.
JD195145 - Sequence 176169 from Patent EP1572962.
JD386468 - Sequence 367492 from Patent EP1572962.
JD173411 - Sequence 154435 from Patent EP1572962.
AK097259 - Homo sapiens cDNA FLJ39940 fis, clone SPLEN2022522.
AK307300 - Homo sapiens cDNA, FLJ97248.

-  Other Names for This Gene
  Alternate Gene Symbols: D6RAM3, D6RAM3_HUMAN, D6RAV2, DOK3 , ENST00000510898.1, ENST00000510898.2, ENST00000510898.3, ENST00000510898.4, ENST00000510898.5, ENST00000510898.6, NM_024872, uc323gwk.1, uc323gwk.2
UCSC ID: ENST00000510898.7_8
RefSeq Accession: NM_001308236.3
Protein: D6RAM3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.