ID:DNSL3_HUMAN DESCRIPTION: RecName: Full=Deoxyribonuclease gamma; Short=DNase gamma; EC=3.1.21.-; AltName: Full=DNase I homolog protein DHP2; AltName: Full=Deoxyribonuclease I-like 3; Short=DNase I-like 3; AltName: Full=Liver and spleen DNase; Short=LS-DNase; Short=LSD; Flags: Precursor; FUNCTION: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units. COFACTOR: Calcium. COFACTOR: Magnesium. ENZYME REGULATION: Inhibited by zinc. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is about 7.2; SUBCELLULAR LOCATION: Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus. TISSUE SPECIFICITY: Liver and spleen. DISEASE: Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16) [MIM:614420]. A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. SIMILARITY: Belongs to the DNase I family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13609
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000737 DNA catabolic process, endonucleolytic GO:0002283 neutrophil activation involved in immune response GO:0002673 regulation of acute inflammatory response GO:0006259 DNA metabolic process GO:0006308 DNA catabolic process GO:0006309 apoptotic DNA fragmentation GO:0006915 apoptotic process GO:0010623 programmed cell death involved in cell development GO:0012501 programmed cell death GO:0070948 regulation of neutrophil mediated cytotoxicity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
