Human Gene DIDO1 (ENST00000266070.8_9) from GENCODE V47lift37

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Description: death inducer-obliterator 1, transcript variant 4 (from RefSeq NM_033081.3)
Gencode Transcript: ENST00000266070.8_9
Gencode Gene: ENSG00000101191.17_13
Transcript (Including UTRs)
Position: hg19 chr20:61,509,090-61,569,304 Size: 60,215 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr20:61,510,585-61,542,964 Size: 32,380 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:61,509,090-61,569,304)			mRNA (may differ from genome)		Protein (2240 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DIDO1_HUMAN DESCRIPTION: RecName: Full=Death-inducer obliterator 1; Short=DIO-1; Short=hDido1; AltName: Full=Death-associated transcription factor 1; Short=DATF-1; FUNCTION: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). TISSUE SPECIFICITY: Ubiquitous. MISCELLANEOUS: Defects in DIDO1 may be a cause of myeloid neoplasms. SIMILARITY: Contains 1 PHD-type zinc finger. SIMILARITY: Contains 1 TFIIS central domain. SEQUENCE CAUTION: Sequence=BAA20791.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DIDO1 Diseases sorted by gene-association score: colorectal adenoma (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C553817 7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one C547126 AZM551248 D000535 Aluminum D001554 Benzene D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002794 Choline D002922 Ciguatoxins D003300 Copper D019327 Copper Sulfate D005492 Folic Acid D005557 Formaldehyde D007213 Indomethacin D007854 Lead D008713 Methimazole D008715 Methionine D011078 Polychlorinated Biphenyls D011441 Propylthiouracil D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C006780 bisphenol A C025589 ochratoxin A C045950 propiconazole

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 12.23 RPKM in Uterus Total median expression: 408.27 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-128.10	356	-0.360	Picture	PostScript	Text
3' UTR	-362.60	1495	-0.243	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012921 - SPOC_C
IPR003618 - TFIIS_cen_dom
IPR017890 - TFS2M
IPR019786 - Zinc_finger_PHD-type_CS
IPR011011 - Znf_FYVE_PHD
IPR001965 - Znf_PHD
IPR019787 - Znf_PHD-finger
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00628 - PHD-finger
PF07500 - Transcription factor S-II (TFIIS), central domain
PF07744 - SPOC domain

SCOP Domains:
46942 - Elongation factor TFIIS domain 2
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q9BTC0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006915 apoptotic process GO:0097190 apoptotic signaling pathway Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm GO:0005819 spindle GO:0005856 cytoskeleton

Descriptions from all associated GenBank mRNAs


	AL133063 - Homo sapiens mRNA; cDNA DKFZp434P1115 (from clone DKFZp434P1115); partial cds. AY481572 - Homo sapiens death inducer-obliterator-3 (DIDO3) mRNA, complete cds. BC012757 - Homo sapiens chromosome 20 open reading frame 158, mRNA (cDNA clone IMAGE:3630351). JD263390 - Sequence 244414 from Patent EP1572962. JD088083 - Sequence 69107 from Patent EP1572962. JD048609 - Sequence 29633 from Patent EP1572962. JD511416 - Sequence 492440 from Patent EP1572962. JD214411 - Sequence 195435 from Patent EP1572962. JD501011 - Sequence 482035 from Patent EP1572962. JD539540 - Sequence 520564 from Patent EP1572962. JD462711 - Sequence 443735 from Patent EP1572962. JD420047 - Sequence 401071 from Patent EP1572962. JD055413 - Sequence 36437 from Patent EP1572962. JD058559 - Sequence 39583 from Patent EP1572962. JD373448 - Sequence 354472 from Patent EP1572962. JD289361 - Sequence 270385 from Patent EP1572962. KJ906067 - Synthetic construct Homo sapiens clone ccsbBroadEn_15737 DIDO1 gene, encodes complete protein. JD418213 - Sequence 399237 from Patent EP1572962. JD328606 - Sequence 309630 from Patent EP1572962. JD191257 - Sequence 172281 from Patent EP1572962. JD064955 - Sequence 45979 from Patent EP1572962. JD535394 - Sequence 516418 from Patent EP1572962. JD157408 - Sequence 138432 from Patent EP1572962. JD135114 - Sequence 116138 from Patent EP1572962. JD480017 - Sequence 461041 from Patent EP1572962. JD123729 - Sequence 104753 from Patent EP1572962. JD334708 - Sequence 315732 from Patent EP1572962. JD302094 - Sequence 283118 from Patent EP1572962. JD383816 - Sequence 364840 from Patent EP1572962. JD457808 - Sequence 438832 from Patent EP1572962. JD409582 - Sequence 390606 from Patent EP1572962. JD390019 - Sequence 371043 from Patent EP1572962. JD227918 - Sequence 208942 from Patent EP1572962. JD195492 - Sequence 176516 from Patent EP1572962. JD465183 - Sequence 446207 from Patent EP1572962. JD448139 - Sequence 429163 from Patent EP1572962. JD043708 - Sequence 24732 from Patent EP1572962. JD449480 - Sequence 430504 from Patent EP1572962. JD218275 - Sequence 199299 from Patent EP1572962. JD386309 - Sequence 367333 from Patent EP1572962. JD266067 - Sequence 247091 from Patent EP1572962. JD150702 - Sequence 131726 from Patent EP1572962. JD187627 - Sequence 168651 from Patent EP1572962. JD056854 - Sequence 37878 from Patent EP1572962. JD405125 - Sequence 386149 from Patent EP1572962. JD083845 - Sequence 64869 from Patent EP1572962. JD258668 - Sequence 239692 from Patent EP1572962. JD053856 - Sequence 34880 from Patent EP1572962. JD253255 - Sequence 234279 from Patent EP1572962. JD460229 - Sequence 441253 from Patent EP1572962. AY481571 - Homo sapiens death inducer-obliterator-2 (DIDO2) mRNA, complete cds. AB002331 - Homo sapiens KIAA0333 mRNA. BC137177 - Homo sapiens death inducer-obliterator 1, mRNA (cDNA clone MGC:168797 IMAGE:9021174), complete cds. AB385309 - Synthetic construct DNA, clone: pF1KA0333, Homo sapiens DIDO1 gene for death-inducer obliterator 1, complete cds, without stop codon, in Flexi system. JD550640 - Sequence 531664 from Patent EP1572962. BC014615 - Homo sapiens cDNA clone IMAGE:3532298, containing frame-shift errors. AK002127 - Homo sapiens cDNA FLJ11265 fis, clone PLACE1009158. BC014489 - Homo sapiens death inducer-obliterator 1, mRNA (cDNA clone IMAGE:4901057), complete cds. BC000770 - Homo sapiens death inducer-obliterator 1, mRNA (cDNA clone IMAGE:3506207), complete cds. BC004237 - Homo sapiens death inducer-obliterator 1, mRNA (cDNA clone IMAGE:2959493), complete cds. KJ902197 - Synthetic construct Homo sapiens clone ccsbBroadEn_11591 DIDO1 gene, encodes complete protein. KJ893224 - Synthetic construct Homo sapiens clone ccsbBroadEn_02618 DIDO1 gene, encodes complete protein. DQ893020 - Synthetic construct clone IMAGE:100005650; FLH191734.01X; RZPDo839G0577D death inducer-obliterator 1 (DIDO1) gene, encodes complete protein. DQ896265 - Synthetic construct Homo sapiens clone IMAGE:100010725; FLH191730.01L; RZPDo839G0567D death inducer-obliterator 1 (DIDO1) gene, encodes complete protein. CU674396 - Synthetic construct Homo sapiens gateway clone IMAGE:100017696 5' read DIDO1 mRNA. CU678624 - Synthetic construct Homo sapiens gateway clone IMAGE:100017409 5' read DIDO1 mRNA. JD074292 - Sequence 55316 from Patent EP1572962. JD093484 - Sequence 74508 from Patent EP1572962. JD316225 - Sequence 297249 from Patent EP1572962. JD045051 - Sequence 26075 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BTC0 (Reactome details) participates in the following event(s): R-HSA-1221632 Meiotic synapsis R-HSA-1500620 Meiosis R-HSA-1474165 Reproduction R-HSA-1640170 Cell Cycle

Other Names for This Gene


	Alternate Gene Symbols: A8MY65, B9EH82, C20orf158, DATF1, DIDO1_HUMAN, E1P5I1, ENST00000266070.1, ENST00000266070.2, ENST00000266070.3, ENST00000266070.4, ENST00000266070.5, ENST00000266070.6, ENST00000266070.7, KIAA0333, NM_033081, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q4VXV8, Q4VXV9, Q96D72, Q9BQW0, Q9BTC0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6, uc317ige.1, uc317ige.2 UCSC ID: ENST00000266070.8_9 RefSeq Accession: NM_033081.3 Protein: Q9BTC0 (aka DIDO1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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