Human Gene DHX15 (ENST00000336812.5_7) from GENCODE V47lift37

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Description: DEAH-box helicase 15 (from RefSeq NM_001358.3)
Gencode Transcript: ENST00000336812.5_7
Gencode Gene: ENSG00000109606.13_9
Transcript (Including UTRs)
Position: hg19 chr4:24,529,098-24,586,177 Size: 57,080 Total Exon Count: 14 Strand: -
Coding Region
Position: hg19 chr4:24,529,547-24,586,016 Size: 56,470 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:24,529,098-24,586,177)			mRNA (may differ from genome)		Protein (795 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DHX15_HUMAN DESCRIPTION: RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; EC=3.6.4.13; AltName: Full=ATP-dependent RNA helicase #46; AltName: Full=DEAH box protein 15; FUNCTION: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (By similarity). CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Interacts with SSB/La. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004997 Ethinyl Estradiol C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D019327 Copper Sulfate D003993 Dibutyl Phthalate D004026 Dieldrin D005472 Fluorouracil D005839 Gentamicins D006861 Hydrogen Peroxide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 35.24 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 767.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-54.70	161	-0.340	Picture	PostScript	Text
3' UTR	-97.60	449	-0.217	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR003593 - AAA+_ATPase
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR002464 - DNA/RNA_helicase_DEAH_CS
IPR011709 - DUF1605
IPR007502 - Helicase-assoc_dom
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain
PF04408 - Helicase associated domain (HA2)
PF07717 - Oligonucleotide/oligosaccharide-binding (OB)-fold

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on O43143


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0003724 RNA helicase activity GO:0003725 double-stranded RNA binding GO:0004004 ATP-dependent RNA helicase activity GO:0004386 helicase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016787 hydrolase activity Biological Process: GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0009636 response to toxic substance GO:0043279 response to alkaloid Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005689 U12-type spliceosomal complex GO:0005730 nucleolus GO:0005737 cytoplasm GO:0016607 nuclear speck GO:0071008 U2-type post-mRNA release spliceosomal complex

Descriptions from all associated GenBank mRNAs


	LF206842 - JP 2014500723-A/14345: Polycomb-Associated Non-Coding RNAs. AK056726 - Homo sapiens cDNA FLJ32164 fis, clone PLACE6000379, highly similar to PUTATIVE PRE-MRNA SPLICING FACTOR RNA HELICASE. AK054614 - Homo sapiens cDNA FLJ30052 fis, clone ADRGL1000067. AK055898 - Homo sapiens cDNA FLJ31336 fis, clone MAMGL1000178, highly similar to PUTATIVE PRE-MRNA SPLICING FACTOR RNA HELICASE. BC047577 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 15, mRNA (cDNA clone IMAGE:4814516), with apparent retained intron. BC035974 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 15, mRNA (cDNA clone MGC:32617 IMAGE:4806964), complete cds. AB001636 - Homo sapiens mRNA for ATP-dependent RNA helicase #46, complete cds. AK303506 - Homo sapiens cDNA FLJ55635 complete cds, highly similar to pre-mRNA-splicing factorATP-dependent RNA helicase DHX15 (EC 3.6.1.-). AF279891 - Homo sapiens dead box protein 15 mRNA, complete cds. LF358454 - JP 2014500723-A/165957: Polycomb-Associated Non-Coding RNAs. LF358455 - JP 2014500723-A/165958: Polycomb-Associated Non-Coding RNAs. LF358457 - JP 2014500723-A/165960: Polycomb-Associated Non-Coding RNAs. LF358459 - JP 2014500723-A/165962: Polycomb-Associated Non-Coding RNAs. LF358465 - JP 2014500723-A/165968: Polycomb-Associated Non-Coding RNAs. LF358470 - JP 2014500723-A/165973: Polycomb-Associated Non-Coding RNAs. LF358471 - JP 2014500723-A/165974: Polycomb-Associated Non-Coding RNAs. LF358472 - JP 2014500723-A/165975: Polycomb-Associated Non-Coding RNAs. LF358473 - JP 2014500723-A/165976: Polycomb-Associated Non-Coding RNAs. LF358474 - JP 2014500723-A/165977: Polycomb-Associated Non-Coding RNAs. LF358478 - JP 2014500723-A/165981: Polycomb-Associated Non-Coding RNAs. LF358479 - JP 2014500723-A/165982: Polycomb-Associated Non-Coding RNAs. LF358480 - JP 2014500723-A/165983: Polycomb-Associated Non-Coding RNAs. LF358481 - JP 2014500723-A/165984: Polycomb-Associated Non-Coding RNAs. LF358491 - JP 2014500723-A/165994: Polycomb-Associated Non-Coding RNAs. JD056496 - Sequence 37520 from Patent EP1572962. MA442419 - JP 2018138019-A/14345: Polycomb-Associated Non-Coding RNAs. MA594031 - JP 2018138019-A/165957: Polycomb-Associated Non-Coding RNAs. MA594032 - JP 2018138019-A/165958: Polycomb-Associated Non-Coding RNAs. MA594034 - JP 2018138019-A/165960: Polycomb-Associated Non-Coding RNAs. MA594036 - JP 2018138019-A/165962: Polycomb-Associated Non-Coding RNAs. MA594042 - JP 2018138019-A/165968: Polycomb-Associated Non-Coding RNAs. MA594047 - JP 2018138019-A/165973: Polycomb-Associated Non-Coding RNAs. MA594048 - JP 2018138019-A/165974: Polycomb-Associated Non-Coding RNAs. MA594049 - JP 2018138019-A/165975: Polycomb-Associated Non-Coding RNAs. MA594050 - JP 2018138019-A/165976: Polycomb-Associated Non-Coding RNAs. MA594051 - JP 2018138019-A/165977: Polycomb-Associated Non-Coding RNAs. MA594055 - JP 2018138019-A/165981: Polycomb-Associated Non-Coding RNAs. MA594056 - JP 2018138019-A/165982: Polycomb-Associated Non-Coding RNAs. MA594057 - JP 2018138019-A/165983: Polycomb-Associated Non-Coding RNAs. MA594058 - JP 2018138019-A/165984: Polycomb-Associated Non-Coding RNAs. MA594068 - JP 2018138019-A/165994: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O43143 (Reactome details) participates in the following event(s): R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA

Other Names for This Gene


	Alternate Gene Symbols: DBP1 , DDX15, DHX15 , DHX15_HUMAN, ENST00000336812.1, ENST00000336812.2, ENST00000336812.3, ENST00000336812.4, NM_001358, O43143, Q9NQT7, uc317upu.1, uc317upu.2 UCSC ID: ENST00000336812.5_7 RefSeq Accession: NM_001358.3 Protein: O43143 (aka DHX15_HUMAN or DD15_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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