ID:DEP1A_HUMAN DESCRIPTION: RecName: Full=DEP domain-containing protein 1A; FUNCTION: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. SUBUNIT: Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224. SUBCELLULAR LOCATION: Nucleus. Note=Co-localizes with ZNF224 at the nucleus. TISSUE SPECIFICITY: Expressed in testis. Up-regulated in bladder cancer cells (at protein level). SIMILARITY: Contains 1 DEP domain. SIMILARITY: Contains 1 Rho-GAP domain. SEQUENCE CAUTION: Sequence=AAH03511.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91201.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14246.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14246.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=CAI22441.1; Type=Erroneous gene model prediction; Sequence=CAI22443.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TB30
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
