Human Gene DENND4A (ENST00000443035.8_10) from GENCODE V47lift37

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Description: DENN domain containing 4A, transcript variant 3 (from RefSeq NM_001320835.1)
Gencode Transcript: ENST00000443035.8_10
Gencode Gene: ENSG00000174485.16_14
Transcript (Including UTRs)
Position: hg19 chr15:65,951,461-66,084,631 Size: 133,171 Total Exon Count: 33 Strand: -
Coding Region
Position: hg19 chr15:65,954,189-66,048,788 Size: 94,600 Coding Exon Count: 31

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:65,951,461-66,084,631)			mRNA (may differ from genome)		Protein (1907 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D002945 Cisplatin D016572 Cyclosporine D007545 Isoproterenol D013749 Tetrachlorodibenzodioxin D014810 Vitamin E C006780 bisphenol A C400082 bortezomib C045651 epigallocatechin gallate C051890 irinotecan C017096 n-butoxyethanol C027373 potassium chromate(VI) C015559 trimellitic anhydride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 17.55 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 177.35 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-169.40	385	-0.440	Picture	PostScript	Text
3' UTR	-668.12	2728	-0.245	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AL833317 - Homo sapiens mRNA; cDNA DKFZp313L197 (from clone DKFZp313L197). AF534403 - Homo sapiens c-MYC promoter-binding protein IRLB (IRLB) mRNA, complete cds. BC041706 - Homo sapiens DENN/MADD domain containing 4A, mRNA (cDNA clone MGC:48955 IMAGE:5530033), complete cds. AK307411 - Homo sapiens cDNA, FLJ97359. BC028057 - Homo sapiens DENN/MADD domain containing 4A, mRNA (cDNA clone IMAGE:5139692), partial cds. AK091368 - Homo sapiens cDNA FLJ34049 fis, clone FCBBF3000110, weakly similar to CRAG protein. AX746940 - Sequence 465 from Patent EP1308459. AK290292 - Homo sapiens cDNA FLJ77039 partial cds, highly similar to Homo sapiens c-myc promoter binding protein (MYCPBP), mRNA. AK299570 - Homo sapiens cDNA FLJ52112 complete cds, highly similar to C-myc promoter-binding protein. JD481109 - Sequence 462133 from Patent EP1572962. JD073646 - Sequence 54670 from Patent EP1572962. JD442286 - Sequence 423310 from Patent EP1572962. JD420579 - Sequence 401603 from Patent EP1572962. JD237106 - Sequence 218130 from Patent EP1572962. JD550662 - Sequence 531686 from Patent EP1572962. JD245427 - Sequence 226451 from Patent EP1572962. JD067274 - Sequence 48298 from Patent EP1572962. AL832602 - Homo sapiens mRNA; cDNA DKFZp451C1717 (from clone DKFZp451C1717). AK091268 - Homo sapiens cDNA FLJ33949 fis, clone CTONG2018383, highly similar to IRLB. AX746884 - Sequence 409 from Patent EP1308459. AL833384 - Homo sapiens mRNA; cDNA DKFZp667N1914 (from clone DKFZp667N1914). JD313034 - Sequence 294058 from Patent EP1572962. X63417 - Homo sapiens irlB mRNA. EU446866 - Synthetic construct Homo sapiens clone IMAGE:100070244; IMAGE:100012075; FLH258728.01L DENN/MADD domain containing 4A (DENND4A) gene, encodes complete protein. JD499561 - Sequence 480585 from Patent EP1572962. JD045520 - Sequence 26544 from Patent EP1572962. JD173555 - Sequence 154579 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A7I2RAZ6, A0A7I2RAZ6_HUMAN, DENND4A , ENST00000443035.1, ENST00000443035.2, ENST00000443035.3, ENST00000443035.4, ENST00000443035.5, ENST00000443035.6, ENST00000443035.7, NM_001320835, uc320lad.1, uc320lad.2 UCSC ID: ENST00000443035.8_10 RefSeq Accession: NM_001320835.1

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.