Human Gene DECR1 (ENST00000220764.7_10) from GENCODE V47lift37
  Description: 2,4-dienoyl-CoA reductase 1, transcript variant 1 (from RefSeq NM_001359.2)
Gencode Transcript: ENST00000220764.7_10
Gencode Gene: ENSG00000104325.7_15
Transcript (Including UTRs)
   Position: hg19 chr8:91,013,705-91,065,861 Size: 52,157 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr8:91,013,721-91,064,125 Size: 50,405 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:91,013,705-91,065,861)mRNA (may differ from genome)Protein (335 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DECR_HUMAN
DESCRIPTION: RecName: Full=2,4-dienoyl-CoA reductase, mitochondrial; EC=1.3.1.34; AltName: Full=2,4-dienoyl-CoA reductase [NADPH]; Short=4-enoyl-CoA reductase [NADPH]; Flags: Precursor;
FUNCTION: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.
CATALYTIC ACTIVITY: Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.7 uM for NADPH; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA; Vmax=30.3 umol/min/mg enzyme;
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Mitochondrion.
TISSUE SPECIFICITY: Heart = liver = pancreas > kidney >> skeletal muscle = lung.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DECR1";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DECR1
Diseases sorted by gene-association score: 2,4-dienoyl-coa reductase deficiency* (78), hyperlysinemia (12), chronic granulomatous disease (4), suppurative lymphadenitis (1), retinitis pigmentosa 47 (1), parasitic protozoa infectious disease (1), adrenal cortical adenocarcinoma (1), trichosporonosis (1), image syndrome (1), periodontosis (1), d-2-hydroxyglutaric aciduria (1), vulvitis (1), neurodermatitis (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 72.42 RPKM in Heart - Left Ventricle
Total median expression: 987.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00160.000 Picture PostScript Text
3' UTR -378.601736-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom

Pfam Domains:
PF00106 - short chain dehydrogenase
PF08659 - KR domain
PF13561 - Enoyl-(Acyl carrier protein) reductase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1W6U - X-ray MuPIT 1W73 - X-ray MuPIT 1W8D - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q16698
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0070402 NADPH binding

Biological Process:
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC105080 - Homo sapiens 2,4-dienoyl CoA reductase 1, mitochondrial, mRNA (cDNA clone MGC:132740 IMAGE:8144083), complete cds.
BC105082 - Homo sapiens 2,4-dienoyl CoA reductase 1, mitochondrial, mRNA (cDNA clone MGC:132742 IMAGE:8144085), complete cds.
BC143669 - Homo sapiens cDNA clone IMAGE:9052183.
AK300069 - Homo sapiens cDNA FLJ50204 complete cds, highly similar to 2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34).
L26050 - Human mitochondrial 2,4-dienoyl-CoA reductase mRNA, complete cds.
KJ891039 - Synthetic construct Homo sapiens clone ccsbBroadEn_00433 DECR1 gene, encodes complete protein.
U49352 - Human liver 2,4-dienoyl-CoA reductase mRNA, complete cds.
JD314752 - Sequence 295776 from Patent EP1572962.
JD287032 - Sequence 268056 from Patent EP1572962.
JD244486 - Sequence 225510 from Patent EP1572962.
JD499372 - Sequence 480396 from Patent EP1572962.
JD552444 - Sequence 533468 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q16698 (Reactome details) participates in the following event(s):

R-HSA-109343 Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA
R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-8978868 Fatty acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z6B8, DECR, DECR_HUMAN, ENST00000220764.1, ENST00000220764.2, ENST00000220764.3, ENST00000220764.4, ENST00000220764.5, ENST00000220764.6, NM_001359, Q16698, Q2M304, Q93085, SDR18C1, uc317czn.1, uc317czn.2
UCSC ID: ENST00000220764.7_10
RefSeq Accession: NM_001359.2
Protein: Q16698 (aka DECR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.