Human Gene DCPS (ENST00000263579.5_4) from GENCODE V47lift37
  Description: decapping enzyme, scavenger, transcript variant 2 (from RefSeq NM_014026.6)
Gencode Transcript: ENST00000263579.5_4
Gencode Gene: ENSG00000110063.10_8
Transcript (Including UTRs)
   Position: hg19 chr11:126,173,955-126,219,900 Size: 45,946 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr11:126,173,976-126,215,508 Size: 41,533 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:126,173,955-126,219,900)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DCPS_HUMAN
DESCRIPTION: RecName: Full=m7GpppX diphosphatase; EC=3.6.1.59; AltName: Full=DCS-1; AltName: Full=Hint-related 7meGMP-directed hydrolase; AltName: Full=Histidine triad protein member 5; Short=HINT-5; AltName: Full=Scavenger mRNA-decapping enzyme DcpS;
FUNCTION: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
CATALYTIC ACTIVITY: M(7)G5'ppp5'N(3'ppp5'N)(n) + H(2)O = 7- methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)(n).
CATALYTIC ACTIVITY: 7-methylguanosine 5'-diphosphate + H(2)O = 7- methylguanosine 5'-phosphate + phosphate.
SUBUNIT: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Detected in liver, brain, kidney, testis and prostate.
SIMILARITY: Belongs to the HIT family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DCPS
Diseases sorted by gene-association score: al-raqad syndrome* (1329), autosomal recessive non-syndromic intellectual disability* (85), subcutaneous mycosis (6), syndromic intellectual disability (5), intellectual disability (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 555.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.7021-0.271 Picture PostScript Text
3' UTR -1832.504392-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008594 - DcpS/DCS2
IPR019808 - Histidine_triad_CS
IPR011146 - HIT-like
IPR011145 - Scavenger_mRNA_decap_enz_N

Pfam Domains:
PF05652 - Scavenger mRNA decapping enzyme (DcpS) N-terminal
PF11969 - Scavenger mRNA decapping enzyme C-term binding

SCOP Domains:
54197 - HIT-like
102860 - mRNA decapping enzyme DcpS N-terminal domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ST0 - X-ray MuPIT 1ST4 - X-ray MuPIT 1XML - X-ray MuPIT 1XMM - X-ray MuPIT 3BL7 - X-ray MuPIT 3BL9 - X-ray MuPIT 3BLA - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96C86
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000340 RNA 7-methylguanosine cap binding
GO:0004532 exoribonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0050072 m7G(5')pppN diphosphatase activity

Biological Process:
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0036245 cellular response to menadione
GO:0043069 negative regulation of programmed cell death
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045292 mRNA cis splicing, via spliceosome
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component:
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AF532613 - Homo sapiens scavenger mRNA decapping enzyme (DCPS) mRNA, complete cds.
AY040771 - Homo sapiens histidine triad protein member 5 mRNA, complete cds.
AK026554 - Homo sapiens cDNA: FLJ22901 fis, clone KAT05511, highly similar to AF077201 Homo sapiens HSPC015 mRNA.
AK223089 - Homo sapiens mRNA for mRNA decapping enzyme variant, clone: KAT05511.
AK307403 - Homo sapiens cDNA, FLJ97351.
BC014532 - Homo sapiens decapping enzyme, scavenger, mRNA (cDNA clone MGC:13353 IMAGE:4064215), complete cds.
AF077201 - Homo sapiens HSPC015 mRNA, complete cds.
CU677035 - Synthetic construct Homo sapiens gateway clone IMAGE:100018137 5' read DCPS mRNA.
HQ447210 - Synthetic construct Homo sapiens clone IMAGE:100070509; CCSB006288_03 decapping enzyme, scavenger (DCPS) gene, encodes complete protein.
KJ898699 - Synthetic construct Homo sapiens clone ccsbBroadEn_08093 DCPS gene, encodes complete protein.
AY077684 - Homo sapiens heat shock-like protein 1 (HSL1) mRNA, complete cds.
GQ891298 - Homo sapiens clone HEL-S-21a epididymis secretory sperm binding protein mRNA, complete cds.
AK090828 - Homo sapiens cDNA FLJ33509 fis, clone BRAMY2005151.
JD369627 - Sequence 350651 from Patent EP1572962.
JD283957 - Sequence 264981 from Patent EP1572962.
JD294046 - Sequence 275070 from Patent EP1572962.
JD472239 - Sequence 453263 from Patent EP1572962.
JD154961 - Sequence 135985 from Patent EP1572962.
JD339514 - Sequence 320538 from Patent EP1572962.
JD169719 - Sequence 150743 from Patent EP1572962.
JD424716 - Sequence 405740 from Patent EP1572962.
JD468125 - Sequence 449149 from Patent EP1572962.
JD395463 - Sequence 376487 from Patent EP1572962.
JD425104 - Sequence 406128 from Patent EP1572962.
JD274557 - Sequence 255581 from Patent EP1572962.
JD476808 - Sequence 457832 from Patent EP1572962.
JD415001 - Sequence 396025 from Patent EP1572962.
AJ227874 - Homo sapiens partial mRNA; ID YG81-5A.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96C86 (Reactome details) participates in the following event(s):

R-HSA-429961 DCPS scavenges the 7-methylguanosine cap of mRNA
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease
R-HSA-429914 Deadenylation-dependent mRNA decay
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: DCPS_HUMAN, DCS1, ENST00000263579.1, ENST00000263579.2, ENST00000263579.3, ENST00000263579.4, HINT5, HSPC015, NM_014026, Q8NHL8, Q96C86, Q9Y2S5, uc317hkp.1, uc317hkp.2
UCSC ID: ENST00000263579.5_4
RefSeq Accession: NM_014026.6
Protein: Q96C86 (aka DCPS_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.