Human Gene DCBLD2 (ENST00000326840.11_11) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: discoidin, CUB and LCCL domain containing 2 (from RefSeq NM_080927.4)
Gencode Transcript: ENST00000326840.11_11
Gencode Gene: ENSG00000057019.16_15
Transcript (Including UTRs)
Position: hg19 chr3:98,514,785-98,620,539 Size: 105,755 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr3:98,518,216-98,620,170 Size: 101,955 Coding Exon Count: 16

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:98,514,785-98,620,539)			mRNA (may differ from genome)		Protein (775 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DCBD2_HUMAN DESCRIPTION: RecName: Full=Discoidin, CUB and LCCL domain-containing protein 2; AltName: Full=CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; AltName: Full=Endothelial and smooth muscle cell-derived neuropilin-like protein; Flags: Precursor; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. INDUCTION: Increased in lung cancers during the process of tumor progression. SIMILARITY: Contains 1 CUB domain. SIMILARITY: Contains 1 F5/8 type C domain. SIMILARITY: Contains 1 LCCL domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DCBLD2 Diseases sorted by gene-association score: x-linked nonsyndromic deafness (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015124 8-Bromo Cyclic Adenosine Monophosphate D000082 Acetaminophen D016604 Aflatoxin B1 D016573 Agrochemicals D000643 Ammonium Chloride D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002117 Calcitriol D002251 Carbon Tetrachloride D002945 Cisplatin more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 27.75 RPKM in Cells - Cultured fibroblasts Total median expression: 264.78 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-214.70	369	-0.582	Picture	PostScript	Text
3' UTR	-789.90	3431	-0.230	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000421 - Coagulation_fac_5/8-C_type_dom
IPR000859 - CUB
IPR008979 - Galactose-bd-like
IPR004043 - LCCL

Pfam Domains:
PF00431 - CUB domain
PF00754 - F5/8 type C domain
PF03815 - LCCL domain

SCOP Domains:
49785 - Galactose-binding domain-like
49854 - Spermadhesin, CUB domain
69848 - LCCL domain

ModBase Predicted Comparative 3D Structure on Q96PD2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0030308 negative regulation of cell growth GO:0030522 intracellular receptor signaling pathway GO:0042060 wound healing Cellular Component: GO:0005887 integral component of plasma membrane GO:0009986 cell surface GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	LF210636 - JP 2014500723-A/18139: Polycomb-Associated Non-Coding RNAs. AB073146 - Homo sapiens mRNA for CLCP1, complete cds. BC029658 - Homo sapiens discoidin, CUB and LCCL domain containing 2, mRNA (cDNA clone MGC:30023 IMAGE:4431275), complete cds. AF387547 - Homo sapiens endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) mRNA, complete cds. AK302649 - Homo sapiens cDNA FLJ61618 complete cds, highly similar to Discoidin, CUB and LCCL domain-containing protein 2 precursor. KJ903768 - Synthetic construct Homo sapiens clone ccsbBroadEn_13162 DCBLD2 gene, encodes complete protein. DQ894997 - Synthetic construct Homo sapiens clone IMAGE:100009457; FLH180177.01L; RZPDo839H01131D discoidin, CUB and LCCL domain containing 2 (DCBLD2) gene, encodes complete protein. AK056350 - Homo sapiens cDNA FLJ31788 fis, clone NT2RI2008598, weakly similar to MILK FAT GLOBULE-EGF FACTOR 8 PRECURSOR. D29810 - Homo sapiens mRNA for unknown product, partial cds. CU688730 - Synthetic construct Homo sapiens gateway clone IMAGE:100020054 5' read DCBLD2 mRNA. MA446213 - JP 2018138019-A/18139: Polycomb-Associated Non-Coding RNAs. AF104313 - Homo sapiens unknown mRNA. AK001362 - Homo sapiens cDNA FLJ10500 fis, clone NT2RP2000369. BC016815 - Homo sapiens discoidin, CUB and LCCL domain containing 2, mRNA (cDNA clone IMAGE:4094527), partial cds. JD386879 - Sequence 367903 from Patent EP1572962. JD415486 - Sequence 396510 from Patent EP1572962. LF339627 - JP 2014500723-A/147130: Polycomb-Associated Non-Coding RNAs. LF339626 - JP 2014500723-A/147129: Polycomb-Associated Non-Coding RNAs. JD352689 - Sequence 333713 from Patent EP1572962. JD386178 - Sequence 367202 from Patent EP1572962. LF339625 - JP 2014500723-A/147128: Polycomb-Associated Non-Coding RNAs. JD304460 - Sequence 285484 from Patent EP1572962. LF339624 - JP 2014500723-A/147127: Polycomb-Associated Non-Coding RNAs. JD043327 - Sequence 24351 from Patent EP1572962. JD095675 - Sequence 76699 from Patent EP1572962. JD057782 - Sequence 38806 from Patent EP1572962. LF339623 - JP 2014500723-A/147126: Polycomb-Associated Non-Coding RNAs. JD444426 - Sequence 425450 from Patent EP1572962. JD286346 - Sequence 267370 from Patent EP1572962. JD563325 - Sequence 544349 from Patent EP1572962. LF339622 - JP 2014500723-A/147125: Polycomb-Associated Non-Coding RNAs. JD368244 - Sequence 349268 from Patent EP1572962. JD248913 - Sequence 229937 from Patent EP1572962. JD555429 - Sequence 536453 from Patent EP1572962. JD297810 - Sequence 278834 from Patent EP1572962. JD299845 - Sequence 280869 from Patent EP1572962. JD551483 - Sequence 532507 from Patent EP1572962. LF339621 - JP 2014500723-A/147124: Polycomb-Associated Non-Coding RNAs. JD239163 - Sequence 220187 from Patent EP1572962. JD214124 - Sequence 195148 from Patent EP1572962. JD245402 - Sequence 226426 from Patent EP1572962. JD260727 - Sequence 241751 from Patent EP1572962. JD245362 - Sequence 226386 from Patent EP1572962. LF339620 - JP 2014500723-A/147123: Polycomb-Associated Non-Coding RNAs. JD560800 - Sequence 541824 from Patent EP1572962. LF339619 - JP 2014500723-A/147122: Polycomb-Associated Non-Coding RNAs. JD249984 - Sequence 231008 from Patent EP1572962. LF339618 - JP 2014500723-A/147121: Polycomb-Associated Non-Coding RNAs. JD327778 - Sequence 308802 from Patent EP1572962. JD287995 - Sequence 269019 from Patent EP1572962. JD300056 - Sequence 281080 from Patent EP1572962. JD121661 - Sequence 102685 from Patent EP1572962. JD333705 - Sequence 314729 from Patent EP1572962. JD284175 - Sequence 265199 from Patent EP1572962. JD038746 - Sequence 19770 from Patent EP1572962. LF339617 - JP 2014500723-A/147120: Polycomb-Associated Non-Coding RNAs. JD538496 - Sequence 519520 from Patent EP1572962. JD263798 - Sequence 244822 from Patent EP1572962. JD292697 - Sequence 273721 from Patent EP1572962. JD562474 - Sequence 543498 from Patent EP1572962. JD083055 - Sequence 64079 from Patent EP1572962. JD522524 - Sequence 503548 from Patent EP1572962. JD564757 - Sequence 545781 from Patent EP1572962. LF339616 - JP 2014500723-A/147119: Polycomb-Associated Non-Coding RNAs. JD202768 - Sequence 183792 from Patent EP1572962. JD283241 - Sequence 264265 from Patent EP1572962. JD279714 - Sequence 260738 from Patent EP1572962. LF339615 - JP 2014500723-A/147118: Polycomb-Associated Non-Coding RNAs. LF339614 - JP 2014500723-A/147117: Polycomb-Associated Non-Coding RNAs. BX647140 - Homo sapiens mRNA; cDNA DKFZp686P10171 (from clone DKFZp686P10171). LF339612 - JP 2014500723-A/147115: Polycomb-Associated Non-Coding RNAs. LF339605 - JP 2014500723-A/147108: Polycomb-Associated Non-Coding RNAs. LF339604 - JP 2014500723-A/147107: Polycomb-Associated Non-Coding RNAs. LF339603 - JP 2014500723-A/147106: Polycomb-Associated Non-Coding RNAs. MA575204 - JP 2018138019-A/147130: Polycomb-Associated Non-Coding RNAs. MA575203 - JP 2018138019-A/147129: Polycomb-Associated Non-Coding RNAs. MA575202 - JP 2018138019-A/147128: Polycomb-Associated Non-Coding RNAs. MA575201 - JP 2018138019-A/147127: Polycomb-Associated Non-Coding RNAs. MA575200 - JP 2018138019-A/147126: Polycomb-Associated Non-Coding RNAs. MA575199 - JP 2018138019-A/147125: Polycomb-Associated Non-Coding RNAs. MA575198 - JP 2018138019-A/147124: Polycomb-Associated Non-Coding RNAs. MA575197 - JP 2018138019-A/147123: Polycomb-Associated Non-Coding RNAs. MA575196 - JP 2018138019-A/147122: Polycomb-Associated Non-Coding RNAs. MA575195 - JP 2018138019-A/147121: Polycomb-Associated Non-Coding RNAs. MA575194 - JP 2018138019-A/147120: Polycomb-Associated Non-Coding RNAs. MA575193 - JP 2018138019-A/147119: Polycomb-Associated Non-Coding RNAs. MA575192 - JP 2018138019-A/147118: Polycomb-Associated Non-Coding RNAs. MA575191 - JP 2018138019-A/147117: Polycomb-Associated Non-Coding RNAs. MA575189 - JP 2018138019-A/147115: Polycomb-Associated Non-Coding RNAs. MA575182 - JP 2018138019-A/147108: Polycomb-Associated Non-Coding RNAs. MA575181 - JP 2018138019-A/147107: Polycomb-Associated Non-Coding RNAs. MA575180 - JP 2018138019-A/147106: Polycomb-Associated Non-Coding RNAs. BC007117 - Homo sapiens discoidin, CUB and LCCL domain containing 2, mRNA (cDNA clone IMAGE:4333276), partial cds. LF339597 - JP 2014500723-A/147100: Polycomb-Associated Non-Coding RNAs. LF339596 - JP 2014500723-A/147099: Polycomb-Associated Non-Coding RNAs. LF339594 - JP 2014500723-A/147097: Polycomb-Associated Non-Coding RNAs. LF339593 - JP 2014500723-A/147096: Polycomb-Associated Non-Coding RNAs. JD151225 - Sequence 132249 from Patent EP1572962. JD477951 - Sequence 458975 from Patent EP1572962. JD038615 - Sequence 19639 from Patent EP1572962. JD045331 - Sequence 26355 from Patent EP1572962. JD152140 - Sequence 133164 from Patent EP1572962. JD407760 - Sequence 388784 from Patent EP1572962. JD129618 - Sequence 110642 from Patent EP1572962. JD462616 - Sequence 443640 from Patent EP1572962. JD508365 - Sequence 489389 from Patent EP1572962. JD145874 - Sequence 126898 from Patent EP1572962. MA575174 - JP 2018138019-A/147100: Polycomb-Associated Non-Coding RNAs. MA575173 - JP 2018138019-A/147099: Polycomb-Associated Non-Coding RNAs. MA575171 - JP 2018138019-A/147097: Polycomb-Associated Non-Coding RNAs. MA575170 - JP 2018138019-A/147096: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B7WNL1, CLCP1, D3DN41, DCBD2_HUMAN, ENST00000326840.1, ENST00000326840.10, ENST00000326840.2, ENST00000326840.3, ENST00000326840.4, ENST00000326840.5, ENST00000326840.6, ENST00000326840.7, ENST00000326840.8, ENST00000326840.9, ESDN, NM_080927, Q8N6M4, Q8TDX2, Q96PD2, uc317sdr.1, uc317sdr.2 UCSC ID: ENST00000326840.11_11 RefSeq Accession: NM_080927.4 Protein: Q96PD2 (aka DCBD2_HUMAN or DCB2_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.